213032-75-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
(3,4-DIMETHOXY-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Organic Synthesis:
As a building block in organic synthesis, (3,4-DIMETHOXY-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER is utilized for the creation of complex organic molecules, facilitating advancements in chemical research and product development.
Used in Surface Coating Industry:
(3,4-DIMETHOXY-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER is used as a modifier in surface coatings, enhancing the properties of coatings and providing improved performance in various applications.
Used as a Corrosion Inhibitor:
(3,4-DIMETHOXY-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER has shown potential as an inhibitor for the production of corrosion in metals, making it a valuable asset in industries where metal protection is crucial, such as automotive, aerospace, and construction.
It is important to handle (3,4-DIMETHOXY-PHENYL)-PHOSPHONIC ACID DIETHYL ESTER with care, as it may be hazardous if not properly managed.

Upstream product

• 64-17-5 ethanol 
• 53534-49-9 4-dichlorophosphino-veratrole 
• 91-16-7 1,2-dimethoxybenzene 
• 122-52-1 triethyl phosphite 
• 762-04-9 phosphonic acid diethyl ester 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 

Downstream Products

• 1605306-45-3 C₁₃H₁₈NO₅P 

Relevant academic research and scientific papers

Direct C?H Phosphonylation of Electron-Rich Arenes and Heteroarenes by Visible-Light Photoredox Catalysis

The direct transformation of ubiquitous, but chemically inert C?H bonds into diverse functional groups is an important strategy in organic synthesis that improves the atom economy and faclitates the preparation and modification of complex molecules. In contrast to the wide applications of aryl phosphonates, their synthesis via direct C?H bond phosphonylation is a less explored area. We report here a general, mild, and broadly applicable visible-light photoredox C?H bond phosphonylation method for electron-rich arenes and heteroarenes. The photoredox catalytic protocol utilizes electron-rich arenes and biologically important heteroarenes as substrates, [Ru(bpz)3][PF6]2 as photocatalyst, ammonium persulfate as oxidant, and trialkyl phosphites as the phosphorus source to provide a wide range of aryl phosphonates at ambient temperature under very mild reaction conditions.

Manganese(III)-mediated direct phosphonylation of arenes

Manganese (III)-promoted direct phosphonylation of mono- and disubstituted arenes with dialkylphosphite afforded regioselective dialkylphosphonates in good yields. The reactions can apply to arenes bearing electron-donating groups and electron-withdrawing

Microwave-promoted palladium(II)-catalyzed C-P bond formation by using arylboronic acids or aryltrifluoroborates

The first PdII-catalyzed P arylation has been performed by using palladium acetate, the rigid bidentate ligand dmphen (dmphen=2,9-dimethyl-1,10- phenanthroline), and without the addition of base or acid. Couplings of arylboronic acids or aryl t

A direct and new convenient oxidation: Synthesis of substituted arylphosphonates from aromatics

An easy synthesis of aryl phosphonates by oxidation from aryldichlorophosphines with iodine in good yields is described. Aryldichlorophosphines are obtained by reaction of phosphorous trichloride with some aromatics in presence of various Lewis acids. BiCl3 and Bi(OTf)3 are used for the first time and bismuth trichloride is, for the first time in the case of anisole or thioanisole phosphonylation, used as a true regenerable Lewis acid catalyst in a reaction of direct phosphonylation of aromatics.