213113-08-7

Upstream product

• 213113-07-6 (Z)-1-(3'-methoxy-4'-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)ethene 
• 208450-60-6 (E)-1-(3'-methoxy-4'-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)ethene 
• 61240-20-8 triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide 
• 80410-57-7 3-methoxy-4-nitrobenzaldehyde 
• 80866-88-2 (3-methoxy-4-nitrophenyl)methanol 
• 21852-50-6 3,4,5-trimethoxybenzyl bromide 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 

Relevant academic research and scientific papers

Description anti-mitotic agents which inhibit tubulin polymerization

Methoxy and ethoxy substituted 3-aroyl-2-arylbenzo[b]thiophenes and benzo[b]thiophene analogues are described for use in inhibiting tubulin polymerization. The compounds' use for treating tumor cells is also described. Additional aspects described here are certain diaryl ether benzo[b]thiophene derivatives. Also described are particular analogs derived from dihydronaphthalene which have proven particularly effective. Certain new benzofuran analogs are described, as well as certain sulfur oxide benzo[b]thiophene analogs. Important compounds described herein include the first nitrogen-containing derivatives of combretastatin. These include nitro, amino and azide combrdtastatin derivatives.

Synthesis and biological evaluation of aryl azide derivatives of combretastatin a-4 as molecular probes for tubulin

Two new aryl azides, (Z)-1-(3'-azido-4'-methoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)ethene 9 and (Z)-1-(4'-azido-3'-methoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)ethene 5, modeled after the potent antitumor, antimitotic agent combretastatin A-4 (CA-4)