80410-57-7

Basic information

• Product Name: 3-METHOXY-4-NITROBENZALDEHYDE
• Synonyms: 3-METHOXY-4-NITROBENZALDEHYDE;Benzaldehyde, 3-Methoxy-4-nitro-
• CAS NO: 80410-57-7
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.14548
• Mol File: 80410-57-7.mol
• Article Data: 24

Chemical Properties

• Melting Point: 104 °C
• Boiling Point: 334.8 °C at 760 mmHg
• Flash Point: 171 °C
• Appearance: /
• Density: 1.322 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-METHOXY-4-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-4-NITROBENZALDEHYDE(80410-57-7)
• EPA Substance Registry System: 3-METHOXY-4-NITROBENZALDEHYDE(80410-57-7)

Safety Data

• Hazardous Substances Data: 80410-57-7(Hazardous Substances Data)

Usage

General Description

3-Methoxy-4-nitrobenzaldehyde, also known as P-ANISALDEHYDE, is a yellow crystalline compound with the chemical formula C8H7NO4. It is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and perfumes. 3-Methoxy-4-nitrobenzaldehyde is also used as a starting material for the production of other chemicals, including 3-Methoxy-4-nitrobenzyl alcohol and 1-(3-Methoxy-4-nitrophenyl)ethanone. 3-METHOXY-4-NITROBENZALDEHYDE is classified as a hazardous substance and should be handled with caution.

Upstream product

• 7697-37-2 nitric acid 
• 591-31-1 3-methoxy-benzaldehyde 
• 80866-88-2 (3-methoxy-4-nitrophenyl)methanol 
• 5081-37-8 methyl 3-methoxy-4-nitrobenzoate 
• 118510-03-5 methyl (E)-3-(3-methoxy-4-nitrophenyl)propenoate 
• 5081-36-7 3-methoxy-4-nitrobenzoic acid 
• 100-83-4 meta-hydroxybenzaldehyde 
• 704-13-2 5-formyl-2-nitrophenol 
• 74-88-4 methyl iodide 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 118510-04-6 3-(3-Methoxy-4-nitrophenyl)-2-propenoic acid 
• 77-78-1 dimethyl sulfate 
• 23145-65-5 1-bromomethyl-3-methoxy-4-nitrobenzene 
• 186581-53-3 diazomethane 

Downstream Products

• 145654-39-3 2-(3-methoxy-4-nitrostyryl)pyridine 
• 149555-77-1 O-methyl-3-methoxy-4-nitrobenzaldoxime 
• 129841-10-7 C₈H₇⁽¹⁸⁾FO₂ 
• 208450-60-6 (E)-1-(3'-methoxy-4'-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)ethene 
• 213113-07-6 (Z)-1-(3'-methoxy-4'-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)ethene 
• 383667-13-8 ethyl (E)-3-(3-methoxy-4-nitrophenyl)acrylate 
• 1261571-40-7 C₉H₉NO₆ 
• 1618636-85-3 C₁₀H₁₁NO₆ 
• 1618636-86-4 C₁₀H₁₃NO₄ 
• 1618636-87-5 C₁₀H₁₁N₃O₄ 
• 1618636-88-6 C₉H₉N₃O₄ 
• 1618636-89-7 C₁₈H₂₇N₅O₅ 
• 1618636-90-0 C₃₃H₄₀N₈O₆ 
• 1350900-76-3 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(4-[¹⁸F]fluoro-3-methoxybenzyl)piperazine 

Relevant articles and documents

Probing the Intracellular Dynamics of Nitric Oxide and Hydrogen Sulfide Using an Activatable NIR II Fluorescence Reporter

Understanding the complex interplay among gasotransmitters is of great significance but remains technically challenging. In this study, we present the design and synthesis of a dually responsive BOD-NH-SC reporter for probing the dynamic and alternating existence of NO and H2S in living cells. This designed reporter can repeatedly cycle S-nitrosation and transnitrosation reactions when successively treated with NO and H2S, thus affording the interchange of NIR fluorescence at 645 nm (NO) and NIR II fluorescence at 936 nm (H2S). In light of this unique fluorescence alternation between two colors, we synthesized water-soluble BOD-NH-SC dots to visualize the intracellular dynamics of NO and H2S. These molecular probes thus provide a toolbox to elucidate the interplaying roles of NO and H2S in the complex interaction networks of various signal transduction pathways.

Affinity-Driven Covalent Modulator of the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Cascade

Traditional medicines provide a fertile ground to explore potent lead compounds, yet their transformation into modern drugs is fraught with challenges in deciphering the target that is mechanistically valid for its biological activity. Herein we reveal that (Z)-(+)-isochaihulactone (1) exhibited significant inhibition against multiple-drug-resistant (MDR) cancer cell lines and mice xenografts. NMR spectroscopy showed that 1 resisted an off-target thiolate, thus indicating that 1 was a target covalent inhibitor (TCI). By identifying the pharmacophore of 1 (α,β-unsaturated moiety), a probe derived from 1 was designed and synthesized for TCI-oriented activity-based proteome profiling. By MS/MS and computer-guided molecular biology approaches, an affinity-driven Michael addition of the noncatalytic C247 residue of GAPDH was found to control the “ON/OFF” switch of apoptosis through non-canonically nuclear GAPDH translocation, which bypasses the common apoptosis-resistant route of MDR cancers.

PISTON FOR AN INTERNAL COMBUSTION ENGINE AND METHOD FOR PRODUCING THE PISTON FOR AN INTERNAL COMBUSTION ENGINE

The present invention relates to compounds of general formula (I), wherein A represents an optionally substituted heterocycle group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy, inhibit, or prevent the growth or spread of cells, especially malignant cells, into surrounding tissues implicated in a variety of human and animal diseases.