213127-82-3

Upstream product

• 213127-68-5 dimethyl 2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}malonate 
• 185965-95-1 (difluoro-p-tolylmethyl)phosphonic acid diethyl ester 
• 174678-80-9 diethyl [(4-α-bromomethyl)phenyldifluoromethyl]-phosphonate 
• 624-31-7 4-tolyl iodide 
• 108-05-4 vinyl acetate 
• 213127-72-1 diethyl difluoro{4-[3-hydroxy-2-(hydroxymethyl)propyl]phenyl}methylphosphonate 

Downstream Products

• 213127-91-4 (2S)-3-acetoxy-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propanoic acid 
• 213127-93-6 (2S)-2-{[(benzyloxy)carbonyl]amino}-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate 
• 213127-99-2 (2R)-3-[(tert-butoxycarbonyl)amino]-2-{4-[(diethoxyphosphoryl)(difluoro)methyl]benzyl}propyl acetate 
• 213127-95-8 (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propyl acetate 
• 213128-02-0 diethyl [{4-[(2R)-3-[(tert-butoxycarbonyl)amino]-2-(hydroxymethyl)propyl]phenyl}(difluoro)methyl]phosphonate 
• 213127-97-0 diethyl [(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-hydroxypropyl}phenyl)(difluoro)methyl]phosphonate 
• 150618-05-6 (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propanoic acid 

Relevant academic research and scientific papers

Enzymatic desymmetrization of prochiral 2-benzyl-1,3-propanediol derivatives: A practical chemoenzymatic synthesis of novel phosphorylated tyrosine analogues

(Phosphonomethyl)phenylalanine (Pmp) and (phosphonodifluoromethyl)phenylalanine (F2Pmp) as well as their β-amino acid congeners were prepared as a protecting variant amenable to the peptide synthesis from readily available 2-benzyl-1,3-propandiols possessing either a diethylphosphonomethyl- or diethylphosphonodifluoromethyl functionality at the para-position via the lipase-catalyzed desymmetrization.