21320-99-0

Usage

Explanation

The compound consists of 11 carbon atoms, 8 hydrogen atoms, 2 nitrogen atoms, 1 oxygen atom, and 1 sulfur atom.

Explanation

It contains a pyrimidine ring with different types of atoms (heteratoms) such as nitrogen and sulfur, making it a heterocyclic compound.

Explanation

The compound has a pyrimidine ring as its core structure, which is a six-membered aromatic ring with four carbon atoms and two nitrogen atoms.

Explanation

A thioxo group (a sulfur atom double-bonded to an oxygen atom) is attached to the pyrimidine ring, contributing to the compound's structure and properties.

Explanation

A phenyl group (a six-membered aromatic ring with six carbon atoms) is attached to the pyrimidine ring, further modifying the compound's structure and properties.

Explanation

The compound has been studied for its potential therapeutic effects, including reducing inflammation, inhibiting the growth of microorganisms, and preventing the development and spread of cancer cells.

Explanation

1-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one is used as a starting material or intermediate in the synthesis of various pharmaceutical and agrochemical products.

Explanation

The compound has been investigated for its possible use in the development of new organic synthesis methods and materials with specific properties for various applications.

Type of compound

Heterocyclic compound

Pyrimidine ring

Present

Thioxo group

Present

Phenyl group

Present

Pharmacological activities

Anti-inflammatory, antimicrobial, and anticancer

Building block in synthesis

Pharmaceutical and agrochemical products

Potential applications

Organic synthesis and materials science

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 103-85-5 monophenylthiourea 
• 103-72-0 phenyl isothiocyanate 
• 872492-84-7 4-methylsulfanyl-1-phenylpyrimidine-2(1H)-thione 
• 7424-91-1 methyl 3,3-dimethoxypropionate 
• 100135-20-4 N-(3t-ethoxy-acryloyl)-N'-phenyl-thiourea 

Relevant academic research and scientific papers

Straightforward pyrimidine ring construction: A versatile tool for the synthesis of nucleobase and nucleoside analogues

A general route to 1,2,4-trisubstituted pyrimidines is described in one to three steps from a common key precursor, diazadienium iodide 2. An efficient preliminary [4+2] cyclocondensation reaction between the azabutadiene building block 2 and various iso(thio)cyanates constitutes an original construction of the pyrimidine skeleton. Subsequent structural modifications on the heterocycle allow the elaboration of a 1-substituted pyrimidine library that includes nucleoside analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

An efficient synthesis of 1-substituted uracil ring systems and their thio analogues

A facile and simple regioselective synthesis of uracils and their thio analogues has been achieved by cyclocondensation of a common precursor, diazadienium iodide 1, and isothiocyanates 2a,b. The key step in this synthetic process is the preparation of 4-

Solid-phase synthesis of 4(1H)-quinolone and pyrimidine derivatives based on a new scaffold - Polymer-bound cyclic malonic acid ester

An efficient method for the preparation of polymer-bound cyclic malonic acid ester starting from Merrifield resin has been developed. Reaction of the resin-bound cyclic malonic acid ester with triethyl orthoformate and subsequent double substitution with

Improved One-Step Procedure for the Preparation of 1-Substituted and 1,3-Disubstituted Uracils and 2-Thiouracils

A convenient one-pot procedure for the synthesis of 1-substituted and 1,3-disubstituted uracils and 2-thiouracils consists of acylation of ureas or thioureas with methyl 3,3-dimethoxypropanoate in the presence of a strong base, and acidic work-up.The yields range from 36 to 99percent.In all cases, only one regioisomer is isolated.