213202-55-2

Upstream product

• 91292-74-9 alanine ethyl ester-p-chlorobenzyl shiff base 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 321901-76-2 C₁₂H₁₆BrNO₂*ClH 
• 330795-80-7 (R,S)-4-(4-bromobenzyl)-4-methyl-5-oxo-2-phenyl-oxazolidine-3-carboxylic acid benzyl ester 
• 233585-43-8 (2R,3R)-ethyl 1-benzhydryl-3-(4-bromophenyl)aziridine-2-carboxylate 
• 330455-47-5 N-[(1E)-(4-bromophenyl)methylene]-1,1-diphenylmethanamine 
• 1122-91-4 4-bromo-benzaldehyde 
• 870718-66-4 (2R,3R)-1-Benzhydryl-3-(4-bromo-phenyl)-2-methyl-aziridine-2-carboxylic acid ethyl ester 
• 870718-74-4 (R)-2-(Benzhydryl-amino)-3-(4-bromo-phenyl)-2-methyl-propionic acid ethyl ester 
• 64-17-5 ethanol 

Downstream Products

• 213208-73-2 (5R)-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methyl-1H-imidazole-2,4(3H,5H)-dione 

Relevant academic research and scientific papers

Highly diastereoselective alkylation of aziridine-2-carboxylate esters: Enantioselective synthesis of LFA-1 antagonist BIRT-377

The benzhydryl group is the key: Efficient alkylation of 3-substituted aziridine-2-carboxylates is only possible with N-benzhydryl-protected aziridines and occurs with complete retention of the configuration at the 2-position. Sequential catalytic asymmet

Convenient preparation of highly active phase-transfer catalyst for catalytic asymmetric synthesis of α-alkyl- and α,α-dialkyl- α-amino acids: Application to the short asymmetric synthesis of BIRT-377

A highly active phase-transfer catalyst was conveniently prepared from the known, easily available (S)-4,5,6,4′,5′,6′- hexamethoxybiphenyldicarboxylic acid. This catalyst exhibited the high catalytic performance (0.01-1 mol %) in the asymmetric alkylation

Small molecules useful in the treatment of inflammation disease

Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are:1-acetyl-5-(R)-(4-bromobenzyl)-3-(2,6-dichloropyridin-4-yl)-5-methylimidazoline-2,4-dione;5-(R)-(4-bromobenzyl)-3-(2,6-dichloropyridin-4-yl)-1-ethyl-5-methylimidazoline-2,4-dione; and,5-(R)-(4-bromobenzyl)-3-(2,6-dichloropyridin-4-yl)-5-methylimidazoline-2,4-dione.

Small molecules useful in the treatment of inflammatory disease

Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 5-(R)-(4-bromobenzyl)-3-(3-chloro-5-nitrophenyl)-5-methylimidazoline-2,4-dione; and, 5-(R)-(4-bromobenzyl