213208-73-2Relevant articles and documents
Stereodivergent synthesis of the LFA-1 antagonist BIRT-377 by porcine liver esterase desymmetrization and Curtius rearrangement
Johnson, Aaron,Saunders, Matthew J.,Back, Thomas G.
, p. 1463 - 1469 (2015)
The LFA-1 inhibitor and leukocyte adhesion suppressor BIRT-377 was prepared in high enantiomeric excess by desymmetrization of dimethyl 2-p-bromobenzyl-2-methylmalonate, followed by condensation of the resulting carboxylic acid with 3,5-dichloroaniline, s
Synthesis of potent lymphocyte function-associated antigen-1 inhibitors labeled with carbon-14 and deuterium, part 1
Latli, Bachir,Byrne, Denis,Nummy, Larry,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
experimental part, p. 763 - 768 (2012/02/02)
The lymphocyte function-associated antigen-1 (LFA-1) is an essential component in normal immune system function and is a target for drug discovery for its broad therapeutic potential in treating inflammatory diseases. Here, we report the synthesis of thre
Improved Schoellkopf construction of quaternary α-amino acids: efficient enantioselective synthesis of integrin LFA-1 antagonist BIRT-377
Vassiliou, Stamatia,Magriotis, Plato A.
, p. 1754 - 1757 (2007/10/03)
The Schoellkopf methodology for the asymmetric synthesis of α-amino acids which was previously not applicable to the construction of α,α-dialkylated (quaternary) α-amino acids, has been rendered practical for this purpose and applied in a highly efficient