213208-73-2

Basic information

• Product Name: 2,4-Imidazolidinedione, 5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-5-methyl-, (5R)-
• CAS NO: 213208-73-2
• Molecular Formula: C17H13BrCl2N2O2
• Molecular Weight: 428.112
• Mol File: 213208-73-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2,4-Imidazolidinedione, 5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-5-methyl-, (5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Imidazolidinedione, 5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-5-methyl-, (5R)-(213208-73-2)
• EPA Substance Registry System: 2,4-Imidazolidinedione, 5-[(4-bromophenyl)methyl]-3-(3,5-dichlorophenyl)-5-methyl-, (5R)-(213208-73-2)

Safety Data

• Hazardous Substances Data: 213208-73-2(Hazardous Substances Data)

Upstream product

• 79-22-1 methyl chloroformate 
• 302840-67-1 (2R)-2-amino-3-(4-bromophenyl)-N-(3,5-dichlorophenyl)-2-methyl-propionamide 
• 34893-92-0 3,4-dichlorophenyl isocyanate 
• 213202-55-2 (R)-2-amino-2-methyl-3-(4-bromophenyl)propionic acid ethyl ester 
• 626-43-7 3,5-Dichloroaniline 
• 346578-03-8 (R)-3-(4-bromophenyl)-2-isobutoxycarbonylamino-2-methylpropionic acid methyl ester 
• 321901-73-9 (R)-α-methyl-4-bromophenylalanine methyl ester 
• 91292-74-9 alanine ethyl ester-p-chlorobenzyl shiff base 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 872104-08-0 tert-butyl (R)-2-amino-3-(p-bromophenyl)-2-methylpropanoate 
• 870718-66-4 (2R,3R)-1-Benzhydryl-3-(4-bromo-phenyl)-2-methyl-aziridine-2-carboxylic acid ethyl ester 
• 870718-74-4 (R)-2-(Benzhydryl-amino)-3-(4-bromo-phenyl)-2-methyl-propionic acid ethyl ester 
• 1122-91-4 4-bromo-benzaldehyde 
• 330455-47-5 N-[(1E)-(4-bromophenyl)methylene]-1,1-diphenylmethanamine 

Downstream Products

• 213209-43-9 (R)-1-acetyl-5-(4-bromobenzyl)-3-(3,5-dichlorophenyl)-5-methylimidazolidine-2,4-dione 

Relevant articles and documents

Stereodivergent synthesis of the LFA-1 antagonist BIRT-377 by porcine liver esterase desymmetrization and Curtius rearrangement

The LFA-1 inhibitor and leukocyte adhesion suppressor BIRT-377 was prepared in high enantiomeric excess by desymmetrization of dimethyl 2-p-bromobenzyl-2-methylmalonate, followed by condensation of the resulting carboxylic acid with 3,5-dichloroaniline, s

Synthesis of potent lymphocyte function-associated antigen-1 inhibitors labeled with carbon-14 and deuterium, part 1

The lymphocyte function-associated antigen-1 (LFA-1) is an essential component in normal immune system function and is a target for drug discovery for its broad therapeutic potential in treating inflammatory diseases. Here, we report the synthesis of thre

Improved Schoellkopf construction of quaternary α-amino acids: efficient enantioselective synthesis of integrin LFA-1 antagonist BIRT-377

The Schoellkopf methodology for the asymmetric synthesis of α-amino acids which was previously not applicable to the construction of α,α-dialkylated (quaternary) α-amino acids, has been rendered practical for this purpose and applied in a highly efficient