213252-19-8

Basic information

• Product Name: 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE
• Synonyms: 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE;5-[(2,4-dioxothiazolidin-5-yl)Methyl]-2-Methoxy-N-[[4-(trifluoroMethyl)phenyl]Methyl]benzaMide
• CAS NO: 213252-19-8
• Molecular Formula: C₂₀H₁₇F₃N₂O₄S
• Molecular Weight: 438.42
• Mol File: 213252-19-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 605.4°C at 760 mmHg
• Flash Point: 319.9°C
• Appearance: /
• Density: 1.395g/cm³
• Vapor Pressure: 1.32E-14mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE(213252-19-8)
• EPA Substance Registry System: 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE(213252-19-8)

Safety Data

• Hazardous Substances Data: 213252-19-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H17F3N2O4S/c1-29-15-7-4-12(9-16-18(27)25-19(28)30-16)8-14(15)17(26)24-10-11-2-5-13(6-3-11)20(21,22)23/h2-8,16H,9-10H2,1H3,(H,24,26)(H,25,27,28)

Upstream product

• 186312-73-2 methyl 5-(2,4-dioxothiazolidin-5-yl)methyl-2-methoxy-benzoate 
• 22802-67-1 methyl 2-methoxy-5-aminobenzoate 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 185808-79-1 5-[(2,4-Dioxothiazolidin-5-yl)methyl]-2-methoxybenzoic acid 

Relevant articles and documents

NOVEL STABLE CRYSTAL OF THIAZOLIDINEDIONE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME

A homogeneous crystal having excellent stability which is suitable for the industrial-scale production of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide (KRP-297). The novel crystal of KRP-297 is produced through recrystallization from an alcohol solvent. It is characterized by having diffraction angles (2θ) at at least 9.7°, 15.0°, and 22.5° in X-ray powder diffractometry.

(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents

A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.