213270-36-1

Basic information

• Product Name: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER
• Synonyms: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER , EE98%;(S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER, 98+%, EE 98+;(S)-2-ISOBUTYLSUCCINIC ACID-1-METHYL ESTER, 95%, (98% EE);(S)-2-Isobutylsuccinic acid-1-Methyl ester, (98% ee);(S)-3-METHOXYCARBONYL-5-METHYLHEXANOIC ACID;(S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER;(S)-2-ISOBUTYLSUCCINIC ACID-1-METHYL ESTER
• CAS NO: 213270-36-1
• Molecular Formula: C₉H₁₆O₄
• Molecular Weight: 188.22
• EINECS: -0
• Mol File: 213270-36-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 243.23°C (rough estimate)
• Flash Point: 108°C
• Appearance: /
• Density: 1.0725 (rough estimate)
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.4240 (estimate)
• Storage Temp.: Refrigerator (+4°C)
• Water Solubility: Not miscible or difficult to mix in water.
• BRN: 8110824
• CAS DataBase Reference: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER(213270-36-1)
• EPA Substance Registry System: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER(213270-36-1)

Safety Data

• Safety Statements: 24/25
• RIDADR: UN2810
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 213270-36-1(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow viscous liquid

Uses

(S)-(-)-2-Isobutylsuccinic acid 1-methyl ester is used as a pharmaceutical intermediate.

InChI:InChI=1/C9H16O4/c1-6(2)4-7(5-8(10)11)9(12)13-3/h6-7H,4-5H2,1-3H3,(H,10,11)

Upstream product

• 130165-75-2 (E)-2-(1-isobutylidene)succinic acid 1-methyl ester 
• 78-84-2 isobutyraldehyde 
• 106-65-0 Dimethyl succinate 

Downstream Products

• 927828-11-3 (S)-methyl 4-methyl-2-(2-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-ylamino)-2-oxoethyl)pentanoate 

Relevant articles and documents

A Bulky Three-Hindered Quadrant Bisphosphine Ligand: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes

A bulky three-hindered quadrant bisphosphine ligand, di-1-adamantylphosphino(tert-butylmethylphosphino)methane, named BulkyP*, has been synthesized via a convergent short pathway with chromatography-free procedures. The ligand is a crystalline solid and can be readily handled in air. Its rhodium(I) complex exhibits very high enantioselectivities and catalytic activities in the asymmetric hydrogenation of functionalized alkenes.

Highly enantioselective hydrogenation of itaconic acid derivatives with a chiral bisphospholane-Rh(I) catalyst

The new - commercially in multi-kg quantities available - chiral bisphospholane ligand, catA-Sium M, has been successfully used in the Rh(I)-catalysed enantioselective hydrogenation of itaconic acid derivatives. Chiral β-substituted succinic acid derivati

A Novel Chiral Ferrocenyl Phosphine Ligand from Sugar: Applications in Rh-Catalyzed Asymmetric Hydrogenation Reactions

(Matrix Presented) A new chiral ferrocenyl diphosphine ligand 3 was synthesized from readily available D-mannitol. Rh-complex with this ligand showed high enantioselectivity and reactivity in the asymmetric hydrogenation of dehydroamino acid derivatives and itaconic acid derivatives. Up to over 99% ee and 10 000 TON were achieved with this catalytic system.