213382-40-2

Upstream product

• 133059-43-5 4-bromo-3-fluorobenzaldehyde 
• 1220886-29-2 methyl 4-bromo-5-fluoro-2-nitrobenzoate 
• 1020717-99-0 4-bromo-5-fluoro-2-nitrobenzoic acid 

Downstream Products

• 807640-21-7 carbamic acid, [(4-bromo-5-fluoro-2-nitrophenyl)methyl](5-hydroxypentyl)-, 1,1-dimethylethyl ester 
• 1620239-34-0 benzyl [(3S)-1-(3-{[(3-{[(benzyloxy)carbonyl]amino}-6-fluoro-7-vinylquinolin-2-yl)carbonyl]amino}pyridin-4-yl)piperidin-3-yl]carbamate 
• 1620239-33-9 3-{[(benzyloxy)carbonyl]amino}-6-fluoro-7-vinylquinoline-2-carboxylic acid 
• 1620239-32-8 ethyl 3-{[(benzyloxy)carbonyl]amino}-7-bromo-6-fluoroquinoline-2-carboxylate 
• 1620239-30-6 2-amino-4-bromo-5-fluorobenzaldehyde 

Relevant academic research and scientific papers

QUINOLONE DERIVATIVES AS ANTIBACTERIALS

This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.

BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.