213385-71-8Relevant academic research and scientific papers
3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: A new class of AMPA receptor antagonists
Chimirri, Alba,De Sarro, Giovambattista,De Sarro, Angela,Gitto, Rosaria,Quartarone, Silvana,Zappalà, Maria,Constanti, Andrew,Libri, Vincenzo
, p. 3409 - 3416 (1998)
Synthesis and evaluation of anticonvulsant activity of a series of 2,3- benzodiazepin-4-ones (2) chemically related to 1-(4'-aminophenyl)-4-methyl- 7,8-(methylenedioxy)-5H-2,3-benzodiazepine (1, GYKI 52466) have been reported in our recent publications. C
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives
Gitto, Rosaria,Orlando, Valérie,Quartarone, Silvana,De Sarro, Giovambattista,De Sarro, Angela,Russo, Emilio,Ferreri, Guido,Chimirri, Alba
, p. 3758 - 3761 (2007/10/03)
New cyclofunctionalized 2,3-benzodiazepines characterized by a triazolone or triazindione ring fused on the "c" edge of the heptatomic nucleus have been prepared. These compounds were evaluated as potential anticonvulsant agents, and some of them proved t
Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists
Gitto, Rosaria,Zappala, Maria,De Sarro, Giovambattista,Chimirri, Alba
, p. 129 - 134 (2007/10/03)
2,3-Benzodiazepines represent a class of heterocyclic compounds that interact with AMPA-type glutamate receptors in a noncompetitive manner. These compounds have attracted great interest for their pharmacological effects against acute and chronic neurodeg
Synthesis and anticonvulsant activity of new 11H-triazolo[4,5- c][2,3]benzodiazepines
Chimirri, Alba,Bevacqua, Francesca,Gitto, Rosaria,Quartarone, Silvana,Zappala, Maria,De Sarro, Angela,Maciocco, Lisa,Biggio, Giovanni,De Sarro, Giovambattista
, p. 203 - 212 (2007/10/03)
Starting from the corresponding 3,5-dihydro-4H-2,3-benzodiazepin-4- ones, new 11H-triazolo[4,5-c]-[2,3]benzodiazepines were synthesized and tested for anticonvulsant activity. Seizures were evoked both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice. The pharmacological results revealed that the new tricyclic derivatives show less activity than their precursors.
