213407-05-7Relevant academic research and scientific papers
Synthesis of new 6-(4-chlorophenyl)perhydro-1,3-diazepine-2,4-diones via ureidobutyric acids
Guillon, Jean,Sonnet, Pascal,Boulouard, Michel,Dallemagne, Patrick,Miel, Hugues,Daoust, Martine,Rault, Sylvain
, p. 535 - 539 (1998)
Synthesis of new 6-(4-chlorophenyl)perhydro-1,3-diazepine-2,4-diones was accomplished starting from 4-amino-3-(4-chlorophenyl)butyric acid (Baclofen). The chemical pathway involved the cyclisation of various 3-(4-chlorophenyl)- 4-ureidobutyric acids. However, none of the new derivatives retained the anticonvulsant activity of their six-membered ring homologues, belonging to the phenylpyrimidinedione series which we recently described.
