Journal of Heterocyclic Chemistry p. 535 - 539 (1998)
Update date:2022-08-04
Topics:
Guillon, Jean
Sonnet, Pascal
Boulouard, Michel
Dallemagne, Patrick
Miel, Hugues
Daoust, Martine
Rault, Sylvain
Synthesis of new 6-(4-chlorophenyl)perhydro-1,3-diazepine-2,4-diones was accomplished starting from 4-amino-3-(4-chlorophenyl)butyric acid (Baclofen). The chemical pathway involved the cyclisation of various 3-(4-chlorophenyl)- 4-ureidobutyric acids. However, none of the new derivatives retained the anticonvulsant activity of their six-membered ring homologues, belonging to the phenylpyrimidinedione series which we recently described.
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