213481-01-7

Upstream product

• 41175-50-2 8-hydroxyjulolidine 
• 15781-70-1 malonic acid bis-(2,4,6-trichloro-phenyl) ester 

Downstream Products

• 1441004-13-2 C₃₃H₃₁N₂O₅⁽¹⁺⁾*ClO₄^(1-) 
• 1629670-73-0 C₃₄H₃₁N₂O₉S₂⁽¹⁺⁾*C₂F₃O₂^(1-) 
• 939024-89-2 8-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one 
• 58336-35-9 coumarin-6H 

Relevant academic research and scientific papers

Coumarin base-pair replacement as a fluorescent probe of ultrafast DNA dynamics

The design and synthesis of a novel coumarin C-riboside are described, and is based on the well-known photoprobe Coumarin 102. A diastereofacial selective Heck coupling between a furanoid glycal and a coumarin triflate provided a method for glycoside formation. The coumarin C-glycoside was incorporated synthetically into DNA oligomers, and was used to probe ultrafast dynamics of duplex DNA using time-resolved Stokes shift methods.

Copper(II)-Catalyzed Tandem Reaction: Synthesis of Furo[3,2- c]coumarin Derivatives and Evaluation for Photophysical Properties

An efficient protocol for synthesizing furo[3,2-c]coumarin derivatives is described. The novel reaction could afford the desired furocoumarins with good to excellent yields in a mild and rapid manner. Large substrate scope screening and scale-up preparation have also been accomplished, and selected compounds were evaluated for their photophysical properties.

Straightforward access to water-soluble unsymmetrical sulfoxanthene dyes: Application to the preparation of far-red fluorescent dyes with large stokes' shifts

An efficient synthesis of water-soluble unsymmetrical sulforhodamine/ sulforhodol fluorophores containing a single julolidine fragment is presented. Owing to their valuable spectral properties in aqueous buffers, these dyes, especially those bearing a free aniline or phenol moiety, are valuable components of fluorogenic probes for a variety of biosensing applications. A further extension of this synthetic methodology to unusual phenols, namely 7-N,N-dialkylamino-4-hydroxy coumarins has enabled us to provide a new family water-soluble dyes of large Stokes' shift with far-red spectral features.