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Usage

Uses

Used in Organic Synthesis:
N-methyl-N-(3-nitrophenyl)acetamide is used as a reagent in organic synthesis for the preparation of various compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new and improved products in these industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-methyl-N-(3-nitrophenyl)acetamide is utilized as an intermediate in the manufacturing process of certain drugs. Its unique chemical properties allow it to participate in key reactions, facilitating the production of pharmaceutical compounds that address various health conditions.
Used in Agrochemical Industry:
N-methyl-N-(3-nitrophenyl)acetamide also plays a role in the agrochemical industry, where it is used as an intermediate in the synthesis of various agrochemical products. Its involvement in the production process helps create effective solutions for agricultural applications, such as pesticides and herbicides, to protect crops and enhance yields.
Used in Dye and Pigment Manufacturing:
In the dye and pigment manufacturing industry, N-methyl-N-(3-nitrophenyl)acetamide is employed as an intermediate. Its chemical structure contributes to the creation of a wide range of dyes and pigments used in various applications, including textiles, plastics, and printing inks, adding color and vibrancy to numerous products.
Safety Precautions:
As an irritant, N-methyl-N-(3-nitrophenyl)acetamide requires careful handling to minimize the risk of contact with skin, eyes, and mucous membranes. Proper protective equipment, such as gloves, goggles, and masks, should be worn when working with this chemical to ensure the safety of individuals involved in its production, handling, and use.

Upstream product

• 619-26-1 N-methyl-3-nitroaniline 
• 108-24-7 acetic anhydride 
• 122-28-1 N-(3-nitrophenyl)acetanilide 
• 74-88-4 methyl iodide 
• 619-31-8 N,N-dimethyl-3-nitroaniline 
• 75-36-5 acetyl chloride 

Downstream Products

• 71-50-1 acetate 
• 619-26-1 N-methyl-3-nitroaniline 
• 848678-68-2 4-amino-1-methyl-1,3-dihydro-2H-indol-2-one 
• 61679-27-4 N-(3-aminophenyl)-N-methyl-acetamide 

Relevant academic research and scientific papers

Amide Bond Formation Catalyzed by Recyclable Copper Nanoparticles Supported on Zeolite Y under Mild Conditions

A series of catalysts based on supported copper nanoparticles have been prepared and tested in the amide bond formation from tertiary amines and acid anhydrides, in the presence of tert-butyl hydroperoxide as an oxidant. Copper nanoparticles on zeolite Y (CuNPs/ZY) was found to be the most efficient catalyst for the synthesis of amides, working in acetonitrile as solvent, under ligand- and base-free conditions in air. The products were obtained in good to excellent yields and in short reaction times. The CuNPs/ZY system also exhibited higher catalytic activity than some commercially available copper and iron sources and it was reused in ten reaction cycles without any further pre-treatment. This methodology has been successfully scaled-up to a gram scale with no detriment to the yield.

SELECTIVE KINASE INHIBITORS

Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

PURINE DERIVATIVES

Purine derivatives of Formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.

PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS

Pyrrolopyrimidine derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.

Metasubstituted thiazolidinones, their manufacture and use as a drug

This invention involves thiazolidinone of general formula (I) and its creation and use as inhibitors of polo like kinase (PLK) for the treatment of various diseases.

Amide conformational switching induced by protonation of aromatic substituent

(Matrix presented) Introduction of an electron-withdrawing group on the aromatic ring of N-methylacetanilide decreased the ratio of the cis conformer, and the ratio correlates well with the Hammett σ values of the substituents. These steric properties can be applied to achieve amide conformational swiching by protonation at the aromatic substituent of 4-[bis(dimethylamino)]-N-methylacetanilide or N-[p-(dimethylamino)phenyl]-N-phenylacetamide.

Spectral and Electrooptical Properties of Ring Substituted N-methyl-N-phenylnitramines

Secondary aromatic nitramines absorb in IR at 1517-1536, 1285-1299 and 755-759 cm-1 irrespective of the nature of an aromatic ring.Comparison of the 1H and 13C NMR spectra of ring substituted N-methyl-N-phenylnitrmines indicate that interaction between the substituents is poorly transmitted across the ring. α-Cleavage observed in the mass spectra of nitramines shows that the Ar-N bond is abnormally weak.Dipole moments of N-methyl-N-phenylnitrmines find a simple explanation assuming that the unshared electron pair is shifted towards the aromatic ring only in the presence of electron demanding substituents in conjugated position.The results are incompatible with the solvent-caged-pair theory of the nitramine rearrangement. - Key words: secondary nitramines; NMR; IR; mass spectra; dipole moments; Kerr constants