213550-25-5Relevant academic research and scientific papers
siRNAs WITH AT LEAST TWO LIGANDS AT DIFFERENT ENDS
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Page/Page column 94, (2019/10/29)
There is provided inter alia a conjugate for inhibiting expression of a target gene in a cell, said conjugate comprising a nucleic acid portion and ligand portions, said nucleic acid portion comprising at least one duplex region that comprises at least a
Synthesis and evaluation of RNA transesterification efficiency using stereospecific serinol-terpyridine conjugates
Putnam, William C.,Bashkin, James K.
, p. 1309 - 1323 (2007/10/03)
Six novel artificial ribonucleases were synthesized employing a stereochemically pure abasic serinol backbone residue for attachment of the RNA transesterification agent copper(II) terpyridine. These stereochemically pure abasic residues were synthesized
Incorporation of serinol derived acyclic nucleoside analogues into oligonucleotides: Influence on duplex and triplex formation
Benhida, Rachid,Devys, Michel,Fourrey, Jean-Louis,Lecubin, Florence,Sun, Jian-Sheng
, p. 6167 - 6170 (2007/10/03)
Phosphoramidites 6a-c were readily prepared by an original route and used to incorporate serinol derived units I-III in oligonucleotides which, compared to their natural analogues, exhibited a decreased hybridization capacity for duplex and triplex format
