213599-21-4

Upstream product

• 213599-20-3 1-(2,2-dibromovinyl)-2-iodobenzene 
• 766-50-7 (2-iodophenyl)-acetylene 
• 615-43-0 2-iodophenylamine 
• 137648-47-6 1-iodo-2-ethynylbenzene 
• 265671-00-9 3,3-diethyl-1-(2-iodophenyl)triaz-1-ene 
• 265670-90-4 3,3-diethyl-1-(2-((trimethylsilyl)ethynyl)phenyl)triaz-1-ene 
• 26260-02-6 2-iodobenzaldehyde 

Downstream Products

• 1056775-95-1 C₂₃H₁₆INO₂ 
• 1056775-53-1 C₁₇H₁₂INO₂ 

Relevant academic research and scientific papers

A sequential metal-catalyzed C-N bond formation in the synthesis of 2-amido-indoles

(Chemical Equation Presented) A sequential metal-catalyzed C-N bond formation employing ortho-haloaryl acetylenic bromides is described. The initial amidation is highly selective for C8P-N bond formation, leading to o-haloaryl-substiluted ynami

Efficient synthesis of a complete donor/acceptor bis(aryl)diyne family

A facile route to a family of bis(aryl)diynes containing both an electron donating pyridine ring and an electron accepting iodobenzene has been developed. The convergent synthesis involves the coupling of 2-, 3-, or 4-bromopyridine with TMS-acetylene, followed by deprotection to form the first half of the molecule. Similarly, 2-, 3-, or 4-iodoaniline was coupled to TMS-acetylene after protection of the amine group as a diethyltriazine. After conversion of the triazine to an iodine, deprotection of the acetylene and formation of the corresponding bromophenyl-acetylene, the two halves of the molecule were coupled under Cadiot-Chodkiewicz conditions. Nine new compounds were prepared, each of which was found to thermally polymerize from the melt. None of the compounds underwent photochemical polymerization in the solid-state.

Synthesis of enantiopure estrone via a double heck reaction

A novel efficient catalytic approach to steroids by a double Heck reaction of the vinyl bromides 2 and the CD-building block 3 is presented. The new estrogen analogues 1a and 1b are formed via 23a and 23b in a highly regio- and stereoselective manner in g