213611-22-4

Upstream product

• 98-88-4 benzoyl chloride 
• 63366-59-6 P,P'-methanediyl-bis-phosphonothioic acid tetra-O-ethyl ester 

Downstream Products

• 213611-27-9 Benzoic acid (2S,3S,5R)-3-(diethoxy-thiophosphorylmethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 133272-17-0 1-(5-O-benzoyl-2,3-dideoxy-3-diethoxyphosphorylmethyl-2-O-phenoxythiocarbonyl-β-D-ribofuranosyl)thymine 

Relevant academic research and scientific papers

Stereoselective β-N-glycosylation of 2,3-dideoxyribofuranose derivatives controlled by a methylenephosphonothioate functional group at the 3-position

N-glycolylation of 3-(diethoxyphosphorothioyl)methyl-5-O-benzoyl-l-O- ethyl-2,3-dideoxyriboses 9b and 10b with silylated thymine in the presence of TiCl4 proceeded highly diastereoselectively (92% de) to give the corresponding β-nucleotide analogues in good yield. A remarkable neighboring group participation of the methylenephosphonothioate functionality was observed in the course of the β-N-glycosylation.