213620-92-9Relevant academic research and scientific papers
Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives
Takeuchi, Kumiko,Kohn, Todd J.,Mais, Dale E.,True, Timothy A.,Wyss, Virginia L.,Jakubowski, Joseph A.
, p. 1943 - 1948 (2007/10/03)
Synthesis and initial in vitro evaluation of a novel series of phenyl oxazole derivatives are described. An SAR study of the novel dual-acting TRA/TSI agent has revealed that the lipophilicity of the oxazole amide substituents greatly influences the TRA activity but not the TSI. The chain length of the alkenoic acid side chain affects both TRA and TSI. The optimal chain length for the combined activities was found to be n = 4 (heptenoic acid).
Stereoselectivity in the Wittig Reaction of Aromatic Ketones: Origin of Preference for the Olefin Geometry
Takeuchi, Kumiko,Paschal, Jonathan W.,Loncharich, Richard J.
, p. 156 - 168 (2007/10/02)
Investigation of the stereoselectivity observed in the Wittig reaction of aromatic ketones with "nonstabilized" phosphonium ylides revealed that the nature of the substituent on the phenyl ring of phenyl 3-pyridyl ketone determined the stereoselectivity.G
