213621-63-7Relevant academic research and scientific papers
Synthesis of optically active 4-hydroxypyrazolidin-3-ones as precursors for β-amino-α-hydroxycarboxylic acid derivatives
Woydowski, Rarsten,Liebscher, Juergen
experimental part, p. 567 - 571 (2011/10/09)
The cis or trans-glycidic esters 1 or 7 give ring transformations with hydrazines affording optically active 4-hydroxypyrazolidin-3-ones 3 and 4 or 6 or 9 and 10, respectively, in different regioselectivities. 4-Hydroxypyrazolidin-3-ones 3 and 9 can serve as precursors for enantiomerically pure β-amino-α-hydroxycarboxylic acid amides 5 and 11 by hydrogenation in the presence of Raney-Ni.
