213664-68-7

Basic information

• Product Name: 3-azido-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one
• Synonyms: 3-azido-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one
• CAS NO: 213664-68-7
• Molecular Weight: 407.472
• Mol File: 213664-68-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-azido-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-azido-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one(213664-68-7)
• EPA Substance Registry System: 3-azido-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one(213664-68-7)

Safety Data

• Hazardous Substances Data: 213664-68-7(Hazardous Substances Data)

Upstream product

• 97278-68-7 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine 
• 118684-32-5 [3-[N-(tert-butoxycarbonyl)amino]phenyl]methyl bromide 
• 118684-31-4 tert-butyl N-[3-(hydroxymethyl)phenyl]carbamate 
• 1877-77-6 3-aminobenzenemethanol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 211760-20-2 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-(1-p-tosyl-1H-benzimidazol-5-yl)ureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 211760-13-3 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-[3-[3-[(tetrahydropyran-2-yl)oxy]phenyl]ureido]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 211761-50-1 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-(2-(tert-butyldimethylsilyloxy)phenyl)ureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 211760-08-6 3-(3-(4-benzyloxy)phenylureido)-1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 211760-09-7 (3-{3-[3-(4-hydroxy-phenyl)-ureido]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-phenyl)-carbamic acid tert-butyl ester 
• 247152-86-9 1-N-(3-(N'-(tert-butoxycarbonyl)amino)benzyl)-3-(3-phenylthioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Relevant articles and documents

1,3-Disubstituted benzazepines as neuropeptide Y Y1 receptor antagonists

A novel class of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Through a blind screening we found the compound 1-N-(3-(N' -(tert-butoxycarbonyl)amino)benzyl)-7-methoxy-3-(3)-methylureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (9: IC50 =1.6 μM). Chemical modifications of 9 gave a potent NPY Y1 antagonist 3-(N-(4-hydroxyphenyl)-N0 -methylguanidino)-1-N-(3-(N'-(tert- butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (14c: IC50 =43 nM), which had no affnity for NPY Y2 and Y5 receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.