97278-68-7

Basic information

• Product Name: 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine
• Synonyms: 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine
• CAS NO: 97278-68-7
• Molecular Weight: 202.216
• Mol File: 97278-68-7.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine(97278-68-7)
• EPA Substance Registry System: 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine(97278-68-7)

Safety Data

• Hazardous Substances Data: 97278-68-7(Hazardous Substances Data)

Upstream product

• 86499-22-1 3,3-dichloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one 
• 86499-35-6 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 86499-96-9 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 140700-64-7 3-iodo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 86499-23-2 3-chloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one 

Downstream Products

• 86499-35-6 3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 213664-72-3 1-N-(3-(3-isopropylureido)benzyl)-3-(3-(4-(methoxymethyloxy)phenyl)thioureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Relevant articles and documents

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys

Abstract Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase modulators (GSMs) are presented in this communication. Starting from our azepinone leads, optimization studies toward improving central lowering of Aβ42 led to the discovery of novel benzo-fused azepinones. Several benzazepinones were profiled in vivo and found to lower brain Aβ42 levels in Sprague Dawley rats and transgenic APP-YAC mice in a dose-dependent manner after a single oral dose. Compound 34 was further progressed into a pilot study in our cisterna-magna-ported rhesus monkey model, where we observed robust lowering of CSF Aβ42 levels.

HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Disclosed are compounds having the formula (I) wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

PREPARATION OF DIAZO AND DIAZONIUM COMPOUNDS

A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.