213669-43-3

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 2-(1-hydroxy-2-nitroethyl)pyrrolidine-1-carboxylate is used as a building block or intermediate for the synthesis of complex organic molecules. Its unique structural features make it interesting for potential drug development.
Used in Organic Synthesis:
Tert-butyl 2-(1-hydroxy-2-nitroethyl)pyrrolidine-1-carboxylate is used as a building block or intermediate in the synthesis of complex organic molecules. Its unique structural features allow for further research and exploration of its properties and applications, which may lead to valuable insights and discoveries in the field of chemistry and pharmaceutical science.

Upstream product

• 75-52-5 nitromethane 
• 69610-41-9 Boc-L-Pro-H 

Downstream Products

• 609840-84-8 (S)-2-{(S)-2-[(5-Benzyloxymethyl-isoxazol-3-yl)-hydroxy-methyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid benzyl ester 
• 609840-99-5 (S)-2-{(S)-2-[(5-Benzyloxymethyl-4,5-dihydro-isoxazol-3-yl)-hydroxy-methyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid benzyl ester 
• 609840-87-1 3-{[(S)-1-((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-pyrrolidin-2-yl]-hydroxy-methyl}-isoxazole-4,5-dicarboxylic acid dimethyl ester 
• 609840-93-9 (S)-2-{(S)-2-[Hydroxy-(5-trimethylsilanyl-isoxazol-3-yl)-methyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid benzyl ester 
• 609841-04-5 (S)-2-{(S)-2-[Hydroxy-(5-phenyl-4,5-dihydro-isoxazol-3-yl)-methyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid benzyl ester 
• 609840-90-6 (S)-2-{(S)-2-[Hydroxy-(5-phenyl-isoxazol-3-yl)-methyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid benzyl ester 
• 609841-02-3 (S)-2-{(S)-2-[(5-Cyano-4,5-dihydro-isoxazol-3-yl)-hydroxy-methyl]-pyrrolidine-1-carbonyl}-pyrrolidine-1-carboxylic acid benzyl ester 
• 609840-81-5 (S)-2-[(S)-2-(Hydroxy-isoxazol-3-yl-methyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid benzyl ester 
• 609840-55-3 2-[(5-benzyloxymethyl-isoxazol-3-yl)-hydroxy-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 609840-71-3 2-[(5-benzyloxymethyl-4,5-dihydro-isoxazol-3-yl)-hydroxy-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 609840-63-3 2-[hydroxy-(5-phenyl-isoxazol-3-yl)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 609840-78-0 2-[hydroxy-(5-phenyl-4,5-dihydro-isoxazol-3-yl)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Total synthesis of newbouldine via reductive N-N bond formation

The first total synthesis of newbouldine has been achieved employing a new, reductive N-N bond forming reaction. The asymmetric synthesis confirms that the natural product is a racemate.

Prolylisoxazoles: Potent inhibitors of prolyloligopeptidase with antitrypanosomal activity

Prolylprolylisoxazoles and prolylprolylisoxazolines were synthesized through a 1,3-dipolar cycloaddition reaction. These compounds are potent inhibitors of human and trypanosomal prolyloligopeptidase. They were shown to inhibit Trypanosoma cruzi and Trypanosoma b. brucei in in vitro systems with ED50's in the lower μM range.

Diastereoselective synthesis of (-)-1-methyl-(3S,4R)-3,4-bis((2S)-N- (tert-butyloxycarbonyl)pyrrolidin-2-yl)-2-pyrrolidinone by an asymmetric Michael reaction

Beginning with enantiomerically pure L-proline, (-)-1-methyl-(3S,4R)- 3,4-bis((2S)-N-(tert-butyloxycarbonyl)pyrrolidin-2-yl)-2-pyrrolidinone was prepared in diastereomerically pure form. Taking advantage of the chiral induction of the L-proline derivatives, the intermolecular Michael reaction, used to build the pyrrolidinone ring, was carried out stereoselectively.