609840-93-9Relevant academic research and scientific papers
Prolylisoxazoles: Potent inhibitors of prolyloligopeptidase with antitrypanosomal activity
Bal, Gunther,Van Der Veken, Pieter,Antonov, Dimitri,Lambeir, Anne-Marie,Grellier, Philippe,Croft, Simon L.,Augustyns, Koen,Haemers, Achiel
, p. 2875 - 2878 (2007/10/03)
Prolylprolylisoxazoles and prolylprolylisoxazolines were synthesized through a 1,3-dipolar cycloaddition reaction. These compounds are potent inhibitors of human and trypanosomal prolyloligopeptidase. They were shown to inhibit Trypanosoma cruzi and Trypanosoma b. brucei in in vitro systems with ED50's in the lower μM range.
