213739-25-4Relevant academic research and scientific papers
Facile synthesis and fundamental properties of an: N -methylguanidine-bridged nucleic acid (GuNA[NMe])
Horie, Naohiro,Kumagai, Shinji,Kotobuki, Yutaro,Yamaguchi, Takao,Obika, Satoshi
supporting information, p. 6531 - 6536 (2018/10/02)
An N-methylguanidine-bridged nucleic acid (GuNA[NMe]), a guanidine-bridged nucleic acid (GuNA) bearing a methyl substituent at the bridge, was successfully synthesised and incorporated into oligonucleotides. By employing an acetyl protecting group, GuNA[NMe]-modified oligonucleotides bearing acid-sensitive purine nucleobases were successfully prepared. The obtained GuNA[NMe]-modified oligonucleotides exhibit excellent binding affinity towards the complementary single-stranded RNA and DNA. Furthermore, even a single GuNA[NMe] modification provides robust enzymatic stability, similar to that achieved by the well-established phosphorothioate backbone modification. These data indicate that such a GuNA[NMe] represents a valuable modification for the development of therapeutic oligonucleotides.
Novel aromatic compounds possessing antifungal or antibacterial activity
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Page/Page column 53, (2010/02/06)
The present invention provides novel compounds possessing antibacterial, antifungal, antiviral, anticancer, and/or antiparasitic activities. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds ar
