41306-45-0

Basic information

• Product Name: 1,2-Dimethylisothiourea hydriodate
• Synonyms: 1,2-DIMETHYL-2-THIOPSEUDOUREA HYDRIODIDE;1,2-Dimethyl-2-ThiopseudoureaHydroiodide;1,2-DIMETHYLISOTHIOUREA HYDRIODATE;1,2-DIMETHYL-2-THIOPSEUDOUREA;N,S-Dimethylisothiouronium hydriodide, 98%;1,2-Dimethyl-2-thiopseudourea HI;1,2-Dimethyl-2-thiopseudourea hydriodide 98%;1,2-Dimethylisothiourea hydroiodate
• CAS NO: 41306-45-0
• Molecular Formula: C₃H₈N₂S*HI
• Molecular Weight: 232.09
• Product Categories: Organic Building Blocks;Sulfur Compounds;Thioureas;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds
• Mol File: 41306-45-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 134-136 °C(lit.)
• Boiling Point: 237.7 °C at 760 mmHg
• Flash Point: 97.6 °C
• Appearance: /
• Vapor Pressure: 0.0312mmHg at 25°C
• Solubility: methanol: soluble25mg/mL, clear, colorless
• Sensitive: Hygroscopic
• CAS DataBase Reference: 1,2-Dimethylisothiourea hydriodate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dimethylisothiourea hydriodate(41306-45-0)
• EPA Substance Registry System: 1,2-Dimethylisothiourea hydriodate(41306-45-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 41306-45-0(Hazardous Substances Data)

Usage

General Description

1,2-Dimethyl-2-thiopseudourea hydriodide is a thiourea derivative.

InChI:InChI=1/C3H8N2S.HI/c1-5-3(4)6-2;/h1-2H3,(H2,4,5);1H

Upstream product

• 598-52-7 1-(methyl)-thiourea 
• 74-88-4 methyl iodide 

Downstream Products

• 22059-33-2 S-<2-(3-Methyl-guanidino)-aethyl>-thioschwefelsaeure 
• 17148-62-8 2-(methylamino)-6,7-dimethoxy-4(1H)-quinazolinone 
• 213739-25-4 1,2-dimethyl-3-(tert-butoxycarbonyl)isothiourea 
• 70385-45-4 N,S-dimethyl-N'-(dibenzylphosphono)-isothiourea 
• 156706-47-7 N^G-monomethyl-L-arginine hydrochloride 
• 149806-15-5 1-methyl-2-methylsulfanyl-1H-imidazole-4-carbaldehyde 
• 105956-24-9 1-methyl-2-(methylthio)-1H-imidazole-5-carbaldehyde 
• 99733-14-9 (4-guanidino-butyl)-carbamic acid tert-butyl ester 
• 137694-74-7 N-monomethyl-D-arginine 
• 93103-92-5 N-(4-Bromo-benzo[b]thiophen-2-ylmethyl)-N'-methyl-guanidine; compound with toluene-4-sulfonic acid 
• 73992-65-1 C₁₂H₁₉N₂O₃PS 
• 58537-02-3 2-(4-fluorophenyl)methylamino-N-(methylamino)(methylthio)methylene-3-pyridinecarboxamide 
• 17035-90-4 NMMA 
• 95881-59-7 C₉H₁₃N₃O₂S₂ 

Relevant articles and documents

Efficient Catalysts of Acyclic Guanidinium Iodide for the Synthesis of Cyclic Carbonates from Carbon Dioxide and Epoxides under Mild Conditions

We have studied the synthesis of five-membered cyclic carbonates through the cycloaddition of CO 2 to epoxides by using acyclic guanidinium salts. We have found that the cycloaddition reactions proceed smoothly at ordinary temperatures and pressures and result in good yields when acyclic guanidinium iodides are employed as catalysts. Both cation moiety and anion moiety of the guanidinium salts play important roles in their catalytic activity. It is essential to have active hydrogens on the cation moiety as well as an iodide ion as the anion moiety so as to achieve good catalytic activity. Guanidinium iodides with three or more active hydrogens give cyclic carbonates in high yields in polar solvents such as 1-methylpyrrolidin-2-one, whereas the guanidinium iodides with one or two active hydrogens show good catalytic activity in less polar solvents such as 2-methyltetrahydrofuran.

1,3-Disubstituted benzazepines as neuropeptide Y Y1 receptor antagonists

A novel class of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Through a blind screening we found the compound 1-N-(3-(N' -(tert-butoxycarbonyl)amino)benzyl)-7-methoxy-3-(3)-methylureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (9: IC50 =1.6 μM). Chemical modifications of 9 gave a potent NPY Y1 antagonist 3-(N-(4-hydroxyphenyl)-N0 -methylguanidino)-1-N-(3-(N'-(tert- butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (14c: IC50 =43 nM), which had no affnity for NPY Y2 and Y5 receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.