213765-61-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Iodo-5-Hydroxypyridine is used as an intermediate compound for the synthesis of various pharmaceutical products. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
In the field of chemical research, 3-Iodo-5-Hydroxypyridine serves as a valuable compound for studying the properties and reactions of halogenated pyridines. Researchers can use 3-Iodo-5-Hydroxypyridine to explore new reaction pathways, investigate the effects of halogenation on pyridine rings, and develop a deeper understanding of the chemistry involved.
Used in Industrial Applications:
3-Iodo-5-Hydroxypyridine is employed as a specialty chemical in various industrial processes. Its reactivity and unique structure make it suitable for use in the production of certain materials, such as dyes, pigments, or other specialty chemicals. 3-Iodo-5-Hydroxypyridine's potential applications in these industries can be further explored and developed based on its specific properties and reactivity.

Upstream product

• 873302-36-4 3-iodo-5-methoxy-pyridine 
• 74115-13-2 5-bromopyridine-3-ol 
• 918631-14-8 5-trimethylstannanyl-pyridin-3-ol 
• 213766-16-6 3-Cyclopropylmethoxy-5-iodo-pyridine 

Relevant academic research and scientific papers

Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates

The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.

Synthesis and evaluation of 3-123I-iodo-5-[2-(S)-3- pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent

Nicotinic acetylcholine receptors (nAChRs) are downregulated in disease conditions such as Alzheimer's and substance abuse. Presently, 123I-5-IA-85380 is used in human studies and requires over 6 h of scanning time, thus increases patient disco

2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: Synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling

3-(2(S)-Azetidinylmethoxy)pyridine (A-85380) has been identified recently as a ligad with high affinity for nicotinic acetylcholine receptors (nAChRs). Here we report the synthesis and in vitro nAChR binding of a series of 10 pyridine-modified analogues of A-85380. The novel compounds feature a halogen substituent at position 2, 5, or 6 of the 3-pyridyl fragment. Those with the substituents at position 5 or 6, as well as the 2-fluoro analogue, possess subnanomolar affinity for nAChRs in membranes from rat brain. For these ligands, K(i) values range from 11 to 210 pM, as measured by competition with (±)-[3H]epibatidine. In contrast, 2-chloro, 2-bromo, and 2-iodo analogues exhibit substantially lower affinity. AM1 quantum chemical calculations demonstrate that the bulky substituents at position 2 cause notable changes in the molecular geometry. The high-affinity members of the series and (+)-epibatidine display a tight fit superposition of low-energy stable conformers. The new ligands with high affinity for nAChRs may be of interest as pharmacological probes, potential medications, and candidates for developing radiohalogenated tracers to study nAChRs.