21377-11-7

Usage

Molecular weight

264.29 g/mol

Structure

A pyrazole ring with a carboxylic acid group, an amino group, and an ethyl ester group

Applications

Commonly used in pharmaceutical research and drug development as a building block for the synthesis of bioactive compounds

Potential therapeutic uses

Studied for its potential as an anti-cancer agent and as an inhibitor of certain enzymes

Value in medicinal chemistry

Its structure and properties make it a valuable tool for drug discovery.

Upstream product

• 100-44-7 benzyl chloride 
• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 
• 105-56-6 ethyl 2-cyanoacetate 
• 1260243-04-6 ethyl 5-amino-1H-pyrazole-4-carboxylate 

Downstream Products

• 139545-62-3 2,6-Dibenzyl-2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 136603-34-4 1-Benzyl-3-(3-p-tolyl-thioureido)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 136993-32-3 1-Benzyl-3-[3-(4-chloro-phenyl)-thioureido]-1H-pyrazole-4-carboxylic acid ethyl ester 
• 107640-95-9 2-Benzyl-4,5-dihydro-4-oxopyrazolo<3,4-d>pyrimidin 
• 139545-65-6 2-Benzyl-6-phenyl-2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 139545-64-5 3-((E)-1-Amino-2-ethoxycarbonyl-vinylamino)-1-benzyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 138480-71-4 C₁₇H₂₀N₄O₄S 
• 138480-70-3 3-(3-Benzoyl-thioureido)-1-benzyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 138480-68-9 1-Benzyl-3-[3-(4-nitro-phenyl)-thioureido]-1H-pyrazole-4-carboxylic acid ethyl ester 
• 107641-00-9 2-Benzyl-4,5-dihydro-6-methyl-4-oxo-2H-pyrazolo<3,4>pyrimidin 
• 138480-62-3 Ethyl 1-benzyl-3-isothiocyanatopyrazol-4-carboxylate 
• 136603-38-8 N,N'-Di-(pyrazol-3-yl)-thiourea 
• 138480-69-0 1-Benzyl-3-[3-(3-carboxy-phenyl)-thioureido]-1H-pyrazole-4-carboxylic acid ethyl ester 
• 136603-33-3 1-Benzyl-3-[3-(4-carboxy-phenyl)-thioureido]-1H-pyrazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity

Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar IC50 values against prostate (PC3) and breast (MCF7) cancer cell lines. Some notions about structure-activity relationships and plausible mechanism of biological activity are presented.

PROCESS FOR THE PREPARATION OF A PYRAZOLE DERIVATIVE

Disclosed here is a process for the preparation of 3 - amino pyrazole derivative of Formula (I) where R1 = H, C1 - C4 alkyl group or benzyl group or phenyl group; R2 = C1 - C6 alkyl group or benzyl group; comprising a step of reacting the compound of Formula (Ill) with hydrazine hydrate.

4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS

Anti-viral agents of compounds of Formula (I): wherein A, R1, R2, R3 and R4 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.

Pyrazole derivatives and their pharmaceutical use

The present invention relates to a pyrazole derivative represented by formula (I) or (II) STR1 wherein R1 is hydrogen C2-C6 alkyl benzyl or phenyl; each of R2 and R3 is hydrogen, C1-C6 alkyl or benzyl; each of R4 and R5 is hydrogen, C1-C6 alkyl, C3-C6 alkenyl, C3-C8 cycloalkyl, benzyl or phenyl; X is oxygen or sulfur; R5 is hydrogen, C2-C6 alkyl, C3-C6 alkenyl, C3-C8 cycloalkyl or benzyl when R1 is benzyl, R2 is ethyl, R3 is hydrogen, and R4 is hydrogen, and its pharmaceutical use.