21377-11-7

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid, 3-amino-1-(phenylmethyl)-, ethyl ester
• CAS NO: 21377-11-7
• Molecular Formula: C13H15N3O2
• Molecular Weight: 245.281
• Mol File: 21377-11-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid, 3-amino-1-(phenylmethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid, 3-amino-1-(phenylmethyl)-, ethyl ester(21377-11-7)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid, 3-amino-1-(phenylmethyl)-, ethyl ester(21377-11-7)

Safety Data

• Hazardous Substances Data: 21377-11-7(Hazardous Substances Data)

Usage

Molecular weight

264.29 g/mol

Structure

A pyrazole ring with a carboxylic acid group, an amino group, and an ethyl ester group

Applications

Commonly used in pharmaceutical research and drug development as a building block for the synthesis of bioactive compounds

Potential therapeutic uses

Studied for its potential as an anti-cancer agent and as an inhibitor of certain enzymes

Value in medicinal chemistry

Its structure and properties make it a valuable tool for drug discovery.

Upstream product

• 100-44-7 benzyl chloride 
• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 
• 1260243-04-6 ethyl 5-amino-1H-pyrazole-4-carboxylate 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 139545-65-6 2-Benzyl-6-phenyl-2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 107641-00-9 2-Benzyl-4,5-dihydro-6-methyl-4-oxo-2H-pyrazolo<3,4>pyrimidin 
• 36074-57-4 2-benzyl-5-phenyl-6-thioxo-2,5,6,7-tetrahydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 136603-40-2 2-Benzyl-6-phenylamino-2H-pyrazolo[3,4-d][1,3]thiazin-4-one 
• 138480-77-0 C₁₄H₁₇N₅O₂S 
• 136603-41-3 2-Benzyl-6-p-tolylamino-2H-pyrazolo[3,4-d][1,3]thiazin-4-one 
• 136993-33-4 2-Benzyl-5-(4-chloro-phenyl)-6-thioxo-2,5,6,7-tetrahydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 136993-35-6 2-Benzyl-5-(4-methoxy-phenyl)-6-thioxo-2,5,6,7-tetrahydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 136993-39-0 2-Benzyl-5-(4-chloro-phenyl)-6-methylsulfanyl-2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 136993-38-9 (2-Benzyl-4-oxo-6-thioxo-2,4,6,7-tetrahydro-pyrazolo[3,4-d]pyrimidin-5-yl)-acetic acid ethyl ester 
• 136993-45-8 2-Benzyl-5-(4-methoxy-phenyl)-6-methylsulfanyl-2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 138480-84-9 6-(Benzoylamino)-2-benzyl-5-ethyl-4,5-dihydropyrazolo<3,4-d>pyrimidin-4-on 
• 138480-63-4 1-Benzyl-3-(3-m-tolyl-thioureido)-1H-pyrazole-4-carboxylic acid ethyl ester 
• 136993-40-3 2-Benzyl-5-(4-chloro-phenyl)-6-ethylsulfanyl-2,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 

Relevant articles and documents

Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity

Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar IC50 values against prostate (PC3) and breast (MCF7) cancer cell lines. Some notions about structure-activity relationships and plausible mechanism of biological activity are presented.

4-CARBOXY PYRAZOLE DERIVATIVES AS ANTI-VIRAL AGENTS

Anti-viral agents of compounds of Formula (I): wherein A, R1, R2, R3 and R4 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.