213772-92-0

Basic information

• Product Name: [4-(benzyl-tert-butoxycarbonyl-amino)-butyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester
• Synonyms: [4-(benzyl-tert-butoxycarbonyl-amino)-butyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester
• CAS NO: 213772-92-0
• Molecular Weight: 478.673
• Mol File: 213772-92-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [4-(benzyl-tert-butoxycarbonyl-amino)-butyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(benzyl-tert-butoxycarbonyl-amino)-butyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester(213772-92-0)
• EPA Substance Registry System: [4-(benzyl-tert-butoxycarbonyl-amino)-butyl]-(6-hydroxy-hexyl)-carbamic acid tert-butyl ester(213772-92-0)

Safety Data

• Hazardous Substances Data: 213772-92-0(Hazardous Substances Data)

Upstream product

• 4048-33-3 6-amino-1-hexanol 
• 635304-19-7 toluene-4-sulfonic acid 4-(benzyl-tert-butoxycarbonyl-amino)-butyl ester 
• 117654-86-1 4-[N-(t-butoxycarbonyl)-N-[(phenyl)methyl]-amino]butan-1-ol 
• 99858-57-8 4-{[1-Phenyl-meth-(E)-ylidene]-amino}-butan-1-ol 
• 100-52-7 benzaldehyde 
• 59578-63-1 4-(benzylamino)-1-butanol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 213773-07-0 N-(N'-benzyl-N'-tert-butoxycarbonyl-4-aminobutyl)-N-tert-butoxycarbonyl-6-aminohexanoic acid 

Relevant articles and documents

Synthesis and anti-HIV evaluation of new 2',3'-dideoxy-3'-thiacytidine prodrugs

A series of anti-HIV prodrugs possessing various polyaminated side arms have been developed. The incorporation of a N-Boc protected monoamine or diamine side arm into the backbone of the 2',3'-dideoxy-3'-thiacytidine 1 (BCH-189) provided an increase in antiviral potency, which could be several orders magnitude greater than the parent drug (1) depending on the cell culture systems used (MT-4 or MDMs). Twenty six 2',3'-dideoxy-3'-thiacytidine prodrugs which differ from each other by the length, the nature of the 5'-O function and the 5'-O or/and N-4 position on the nucleoside moiety were synthesized. Among this new series of prodrugs, several congeners (12c and 12a) were found to inhibit HIV-1 replication in cell culture with 50% effective concentrations EC50 of 10 and 50 nM respectively, in MT-4 cells. Compound 12c was found more active on infected MDMs cells with 50% effective concentration of 0.01 nM. The synthesis and the antiviral properties of these compounds are discussed.