2138-38-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone is used as an intermediate in the synthesis of pharmaceuticals for its ability to be transformed into a range of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone is used as a precursor for the production of various agrochemicals, contributing to its role in the development of pesticides and other agricultural products.
Used in Industrial Chemicals Production:
1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone is also utilized in the synthesis of other industrial chemicals, highlighting its broad applicability across different sectors.
Used in the Synthesis of Stimulant Drugs:
1-(4-Chlorophenyl)-3-(dimethylamino)-1-propanone is a known precursor in the synthesis of amphetamine and cathinone derivatives, which are used as stimulant drugs. However, due to its psychoactive properties and potential for illicit use, its production and use are regulated and controlled in many countries.

Upstream product

• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 99-91-2 para-chloroacetophenone 
• 124-40-3 dimethyl amine 
• 33797-51-2 eschenmoser's salt 
• 1826-67-1 vinyl magnesium bromide 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 

Downstream Products

• 76852-11-4 1-(4-Chloro-phenyl)-3-dimethylamino-propan-1-one O-(2-amino-ethyl)-oxime 
• 40394-87-4 4-(4-chloro-phenyl)-4-oxo-butyronitrile 
• 477313-11-4 AC 7954 hydrochloride 
• 885672-69-5 1-(4-chlorophenyl)-N³,N³-dimethylpropane-1,3-diamine 
• 885672-64-0 1-(4-chlorophenyl)-3-dimethylamino-propyl 2-methyl-benzoate 
• 885672-75-3 N-[1-(4-chlorophenyl)-3-dimethylamino-propyl]-2-methyl-benzamide 
• 885673-16-5 N-[1-(4-chlorophenyl)-3-dimethylaminopropyl]-2-phenylacetamide 

Relevant academic research and scientific papers

Synthesis and pharmacological investigation of aralkyl diamine derivatives as potential triple reuptake inhibitors

A series of aralkyl diamine derivatives were designed, synthesized, and evaluated for their triple reuptake inhibitory abilities. Compounds 18c (5-HT, NE, DA, IC50 = 389, 69, 238 nM), 36a (5-HT, NE, DA, IC50 = 378, 477, 247 nM), and

ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANT

Aralkyl diamine derivative of the following formula, pharmaceutically acceptable salts or uses thereof as antidepressants. The derivatives have triplex inhibiting activities of the reuptake of 5-HT, dopamine and noradrenalin, which can be administered to the patients in need of such treatment in the form of compositions orally or injectedly et al.

Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors

A series of 3-aryl-3-azolylpropan-1-amines was prepared and screened for its capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In

Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors

We report the discovery of the pyrimido-diazepine scaffolds as novel adenine mimics. Structure-based design led to the discovery of analogs with potent inhibitory activity against receptor tyrosine kinases, such as KDR, Flt3 and c-Kit. Compound 14 exhibited low nanomolar KDR enzymatic and cellular potencies (IC50 = 9 and 52 nM, respectively).

Anticonvulsant activity of semicarbazone derivatives of Mannich bases

A series of semicarbazones of semicarbazide/p-chlorophenyl semicarbazide and Mannich bases of acetophenone/p-chloroacetophenone has been synthesized and their anticonvulsant activity screened against MES and scPTZ test. p-Chlorophenyl semi-carbazone of N,N-dimethylaminopropiophenone has been found to be the most active in all these tests.

A CONVENIENT SYNTHESIS OF 1H-1,2,4-TRIAZOL-1-YL-PROPAN-3-ONE DERIVATIVES BY MODIFIED MANNICH REACTION

1H-1,2,4-Triazol-yl-propan-3-ones were synthesized regioselectively using a modified Mannich reaction.Reactions of enones and Mannich bases with imidazole are also described.