2138-40-1

Basic information

• Product Name: 3-(dimethylamino)-1-(4-nitrophenyl)propan-1-one
• Synonyms: 3-(Dimethylamino)-1-(4-nitrophenyl)-1-propanone; 1-[3-(dimethylamino)-4-nitrophenyl]propan-1-one
• CAS NO: 2138-40-1
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.2405
• Mol File: 2138-40-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 364.4°C at 760 mmHg
• Flash Point: 174.2°C
• Density: 1.186g/cm³
• Vapor Pressure: 1.69E-05mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 3-(dimethylamino)-1-(4-nitrophenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(dimethylamino)-1-(4-nitrophenyl)propan-1-one(2138-40-1)
• EPA Substance Registry System: 3-(dimethylamino)-1-(4-nitrophenyl)propan-1-one(2138-40-1)

Safety Data

• Hazardous Substances Data: 2138-40-1(Hazardous Substances Data)

Upstream product

• 110-88-3 1,3,5-Trioxan 
• 506-59-2 N,N-dimethylammonium chloride 
• 100-19-6 (4-nitrophenyl)ethanone 
• 78725-73-2 1-(4-Nitro-phenyl)-2-propyn-1-ol 
• 37176-75-3 1-(4-nitrophenyl)-2-propyn-1-one 
• 124-40-3 dimethyl amine 

Downstream Products

• 103095-25-6 2,3-dibromo-1-(4-nitro-phenyl)-propan-1-one 
• 22731-72-2 1-(4-nitrophenyl)prop-2-en-1-one 

Relevant articles and documents

Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.