213907-41-6

Upstream product

• 162439-40-9 (2R)-2-(tert-butoxycarbonylmethyl)-6-(phenylmethoxy)-hexanoic acid 

Downstream Products

• 213907-37-0 (2S,3R)-7-Benzyloxy-3-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-2-hydroxy-heptanoic acid tert-butyl ester 
• 215607-14-0 (2S,3R)-7-Benzyloxy-3-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-2-(1-methyl-2-oxo-1,2-dihydro-quinolin-6-ylmethoxy)-heptanoic acid tert-butyl ester 
• 215607-12-8 (2S,3R)-7-Benzyloxy-3-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-2-(1-methyl-2-oxo-1,2-dihydro-quinolin-6-ylmethoxy)-heptanoic acid 

Relevant academic research and scientific papers

New α-substituted succinate-based hydroxamic acids as TNFα convertase inhibitors

Tumor necrosis factor α convertase (TACE), the enzyme responsible for the processing of proTNFα to TNFα, has been reported to be a metalloproteinase closely related to matrix metalloproteinases (MMPs). Current inhibitors of TACE such as succinate-based hy