21392-45-0

Basic information

• Product Name: (7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid
• Synonyms: 4-Carboxy-7-hydroxycoumarin; 7-Hydroxy-4-coumarinylacetic acid; (7-Hydroxy-2-oxo-2H-chromen-4-yl)acetic acid
• CAS NO: 21392-45-0
• Molecular Formula: C₁₀H₆O₅
• Molecular Weight: 220.1782
• Mol File: 21392-45-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 523.5°C at 760 mmHg
• Flash Point: 214.5°C
• Density: 1.511g/cm³
• Vapor Pressure: 8.72E-12mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: (7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid(21392-45-0)
• EPA Substance Registry System: (7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid(21392-45-0)

Safety Data

• Hazardous Substances Data: 21392-45-0(Hazardous Substances Data)

Usage

General Description

(7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid, also known as umbelliferone acetic acid, is a chemical compound derived from umbelliferone, a natural coumarin found in many plants. It is a white crystalline powder with a slight odor, and is soluble in water and ethanol. (7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid has been studied for its potential therapeutic effects, including its antioxidant, anti-inflammatory, and anti-cancer properties. Additionally, it has been shown to exhibit inhibitory activity against certain enzymes, suggesting its potential use as a pharmaceutical agent. Overall, (7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid is a promising compound with potential applications in the fields of medicine and pharmacology.

Upstream product

• 108-46-3 recorcinol 
• 150-19-6 O-methylresorcine 
• 74802-00-9 7-methoxycoumarin-4-carboxylic acid 
• 74801-79-9 7-methoxy-2-oxo-2H-chromene-4-carboxylic acid methyl ester 
• 1084-45-3 ethyl 7-hydroxy-2-oxo-2H-chromene-4-carboxylate 

Downstream Products

• 89-86-1 4-hydroxysalicylic acid 

Relevant articles and documents

Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms

A novel series of coumarin-4-carboxylate ligands (2a-2l), their Ag(I) complexes (3a-3l) together with a number of their phenanthroline adducts (4d, 4f and 4g) have been synthesised and characterised. The ligands were prepared by either acid or base hydrolysis of their corresponding esters or by demethylation of a methylated acid derivative. The esters (1a-1i) were synthesised by an aromatic electrophilic substitution reaction between the conjugate base of substituted phenols and a vinyltriphenylphosphonium salt. The novel series of Ag(I) carboxylate complexes were prepared by reaction of silver nitrate with the coumarin ligands in aqueous/alcohol solution. The Ag(I) phenanthroline adducts were prepared by reaction of the Ag(I) complex with 1,10-phenanthroline in aqueous/alcohol solution. A selection of complexes were screened for their in vitro antibacterial activity against Pseudomonas aeruginosa grown planktonically or as a biofilm as well as a number of other clinically important strains, Escherichia coli, MRSA and Staphylococcus aureus. The activity against the P. aeruginosa biofilm was found to be significantly greater than against the planktonic bacteria.