1084-45-3

Usage

Uses

Used in Research and Development Laboratories:
ETHYL 7-HYDROXYCOUMARIN-4-CARBOXYLATE is used as a research compound for exploring its potential biological and pharmaceutical properties. It is employed in various chemical, biomedical, and pharmacological research studies to quantify its precise effects and understand its role in medicinal chemistry.
Used in Medicinal Chemistry:
ETHYL 7-HYDROXYCOUMARIN-4-CARBOXYLATE is used as a base structure for developing therapeutic agents. Its potential applications in the pharmaceutical industry make it a valuable compound for creating new drugs and treatments.

InChI:InChI=1/C12H10O5/c1-2-16-12(15)9-6-11(14)17-10-5-7(13)3-4-8(9)10/h3-6,13H,2H2,1H3

Upstream product

• 108-46-3 recorcinol 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 1442461-54-2 C₂₅H₂₇BO₇ 
• 40876-98-0 sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate 
• 108-56-5 diethyl oxaloacetate 
• 98807-33-1 4-Methyl-benzoic acid (3aR,4R,6R,6aR)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 

Downstream Products

• 1427204-04-3 C₁₇H₁₂ClNO₆S 
• 21392-45-0 7-hydroxycoumarin-4-carboxylic acid 
• 1093631-56-1 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-oxo-2H-chromene-4-carboxylic acid 
• 1093631-93-6 ethyl 7-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-2-oxo-2H-chromene-4-carboxylate 

Relevant academic research and scientific papers

A Dual-Response Fluorescent Probe Reveals the H2O2-Induced H2S Biogenesis through a Cystathionine β-Synthase Pathway

The two signaling molecules H2S and H2O2 play key roles in maintaining intracellular redox homeostasis. The biological relationship between H2O2 and H2S remains largely unknown in redox biology. In this study, we rationally designed and synthesized single- and dual-response fluorescent probes for detecting both H2O2 and H2S in living cells. The dual-response probe was shown to be capable of mono- and dual-detection of H2O2 and H2S selectively and sensitively. Detailed bioimaging studies based on the probes revealed that both exogenous and endogenous H2O2 could induce H2S biogenesis in living cells. By using gene-knockdown techniques with bioimaging, the H2S biogenesis was found to be majorly cystathionine β-synthase (CBS)-dependent. Our finding shows the first direct evidence on the biological communication between H2O2 (ROS) and H2S (RSS) in vivo. CBS is responsible: A fluorescent probe with two heads for H2O2 and H2S reveals that both exogenous and endogenous H2O2 molecules can induce endogenous H2S biogenesis on a cystathionine β-synthase (CBS) pathway (see scheme).

Copper oxide catalyzed domino process for the synthesis of substituted 2H-pyran-2-ones and polyhydroxy coumarin derivatives

An efficient method for the synthesis of substituted 2H-pyran-2-ones and polyhydroxy coumarin derivatives has been developed via CuO-catalyzed C-C bond formation followed by intramolecular cyclization reaction by reacting electron-deficient alkynes with 1

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors

The use of selective inhibitors of monoamine oxidase A (MAO-A) and B (MAO-B) holds a therapeutic relevance in the treatment of depressive disorders and Parkinson's disease (PD), respectively. Here, the discovery of a new class of compounds acting as monoamine oxidase inhibitors (MAO-Is) and bearing a 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-alkylacetamide skeleton is reported. 6′-Sulfonyloxy derivatives exhibited outstanding affinities to MAO-A (7.0 nM 50 49 nM, much higher than moclobemide) and a pronounced MAO-A/B selectivity. The corresponding 6′-benzyloxy derivatives showed potent MAO-B inhibition and inverted selectivity profile. The rigid E-geometry of the exocyclic double bond allowed a more efficient binding conformation compared to more flexible and less active 2-(1-benzofuran-3-yl)-N- methylacetamide isomers and 4-N-methylcarboxamidomethylcoumarin analogues. Focused structural modifications and docking simulations enabled the identification of key molecular determinants for high affinity toward both MAO isoforms. These novel MAO-Is may represent promising hits for the development of safer therapeutic agents with a potential against depression, PD, and other age-related neurodegenerative pathologies.

Ethers of 7-hydroxy-coumarin useful as medicaments

The invention provides novel esters of 7-hydroxycoumarin of the formula STR1 in which each of R1 and R2 represents a hydrogen atom, a C1 -C4 alkyl, C2 -C4 alkenyl, carboxy, carboxylate, Cs