21394-38-7

Upstream product

• 102-47-6 3,4-Dichlorophenylmethyl chloride 
• 1268388-07-3 acetic acid 2-methyl-3-phenyl-2-phenylazopropyl ester 
• 17350-84-4 (R)-2-amino-2-methyl-3-phenylpropanoic acid 
• 14603-96-4 (R)-(+)-N-Acetyl-α-methyl-phenylalanin 
• 63726-44-3 (2R)-(+)-2-amino-2-methyl-3-phenylpropionamide 
• 22435-99-0 ethyl (R)-2-amino-2-methyl-3-phenylpropanoate 

Downstream Products

• 868287-50-7 3-(N-methyl-N-(methylsulfonyl)amino)-5-(3-((R)-2-tert-butoxycarbonylamino-1-phenylpropan-2-yl)isoxazol-5-yl)-N-((R)-1-(4-fluorophenyl)ethyl)benzamide 
• 677005-07-1 tert-butyl ((1R)-1-benzyl-1-methyl-2-oxoethyl)carbamate 
• 868286-68-4 tert-butyl (R)-(1-hydroxy-2-methyl-3-phenylpropan-2-yl)carbamate 

Relevant academic research and scientific papers

CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of Formula (I-A), including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF

The invention provides novel beta-secretase inhibitors and methods for their including methods of treating Alzheimer's disease.

Chiral azo compounds: Enantioselective synthesis and transformations into β-amino alcohols and α-amino acids with a quaternary stereocenter

Taking advantage of radical carboaminations producing azo compounds, a new chemo-enzymatic approach to enantiomerically enriched azo alcohols, β-amino alcohols and non-natural (aromatic) amino acids with a quaternary stereocenter is reported.

2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE

The present invention is directed to 2, 4, 6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer’s disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

Chemo-Enzymatic Synthesis of (S)-(+)-Cericlamine and Related Enantiomerically Pure 2,2-Disubstituted-2-aminoethanols

The synthesis of (S)-(+)-cericlamine (S)-1 and related disubstituted amino alcohols is described as an example of the stereoselective synthesis of amino alcohols from disubstituted amino acids and their corresponding amides.Thus, the amino alcohols (S)-1,

Synthesis of enantiomerically pure 2,2-disubstituted-2-amino-ethanols by dissolving metal reduction of a,a-disubstituted amino acid amides

Enantiomerically pure 2,2-disubstituted 2-amino-ethanols are prepared in 65 - 99% yield by reduction of a,a-disubstituted amino acid amides using liquid sodium metal in refluxing 1-propanol.