21399-25-7

Upstream product

• 5465-37-2 (E)-1,4-bis(4-chlorophenyl)but-2-ene-1,4-dione 
• 22760-77-6 4,4'-dichlorodibenzoylacetylene 
• 110-61-2 butanedinitrile 
• 1679-18-1 4-Chlorophenylboronic acid 

Relevant academic research and scientific papers

Syntheses of Pyrroles, Pyridines, and Ketonitriles via Catalytic Carbopalladation of Dinitriles

The first example of the Pd-catalyzed addition of organoboron reagents to dinitriles, as an efficient means of preparing 2,5-diarylpyrroles and 2,6-diarylpyridines, has been discussed here. Furthermore, the highly selective carbopalladation of dinitriles with organoboron reagents to give long-chain ketonitriles has been developed as well. Based on the broad scope of substrates, excellent functional group tolerance, and use of commercially available substrates, the Pd-catalyzed addition reaction of arylboronic acid and dinitriles is expected to be significant in future synthetic procedures.

Mild substituted pyrrosulfamide deprotection method

The invention provides a mild substituted pyrrosulfamide deprotection method and belongs to the field of organic synthesis. Compared with a cyclization method, a synthetic route in a method of preparing polysubstituted pyrrole by directly taking pyrrole as a starting raw material is greatly shortened, and the introducing type of substitutional groups is also more flexible, but when the pyrrole istaken as the raw material, a nitrogen atom on a ring needs to be protected firstly, and after reaction is completed, a protecting group is removed. N,N-dimethyl sulfonamide serving as a group with thehigh electron-withdrawing ability has the great advantages in the aspect of serving as a pyrrole protecting group, but the report in the aspect of removing the protecting group is not seen at present. The novel method is used for removing the protecting group, through the mild method, the group, namely the N,N-dimethyl sulfonamide, on a pyrrole chloride atom is effectively removed, and the basisis laid for preparing the polysubstituted pyrrole. The result indicates that the N,N-dimethyl sulfonamide can be effectively removed through the method, and the method is also of a certain reference significance to halogen removing.

Microwave mediated facile one-pot synthesis of polyarylpyrroles from but-2-ene- and but-2-yne-1,4-diones

Several pyrrole derivates with multiple aryl substituents were prepared conveniently in a one pot-reaction from but-2-ene-1,4-diones and but-2-yne-1,4-diones via hydrogenation of the carbon-carbon double bond/triple bond followed by amination-cyclization. The reaction could be performed with ammonium formate or alkyl/arylammonium formates under Pd/C in polyethylene glycol-200 (PEG-200) under microwave irradiation. Using this procedure, different aryl-substituted pyrroles were prepared. Furthermore, studies on microwave vs thermal conditions indicate faster heating under microwave conditions was responsible for rate enhancement.

One-pot synthesis of pyrrole derivatives from (E)-1,4-diaryl-2-butene-1,4-diones

2,5-Di- and 1,2,5-trisubstituted pyrrole derivatives can be prepared conveniently from (E)-1,4-diaryl-2-butene-1,4-diones in a one-pot operation through domino-pathways via palladium-assisted transfer hydrogenation followed by a Paal-Knorr reaction using ammonium formate and its analogs.