214040-95-6

Basic information

• Product Name: 5-(4-Ethoxycarbonyl-thiazol-2-yl)-6-trifluoromethanesulfonyloxy-pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester
• Synonyms: 5-(4-Ethoxycarbonyl-thiazol-2-yl)-6-trifluoromethanesulfonyloxy-pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester
• CAS NO: 214040-95-6
• Molecular Weight: 544.486
• Mol File: 214040-95-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-Ethoxycarbonyl-thiazol-2-yl)-6-trifluoromethanesulfonyloxy-pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Ethoxycarbonyl-thiazol-2-yl)-6-trifluoromethanesulfonyloxy-pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester(214040-95-6)
• EPA Substance Registry System: 5-(4-Ethoxycarbonyl-thiazol-2-yl)-6-trifluoromethanesulfonyloxy-pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester(214040-95-6)

Safety Data

• Hazardous Substances Data: 214040-95-6(Hazardous Substances Data)

Upstream product

• 214040-92-3 2-(6-Dimethoxymethyl-2-trifluoromethanesulfonyloxy-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester 
• 214040-91-2 2-(6-Dimethoxymethyl-2-oxo-1,2-dihydro-pyridin-3-yl)-thiazole-4-carboxylic acid ethyl ester 
• 185950-49-6 6-Dimethoxymethyl-2-oxo-1,2-dihydro-pyridine-3-carbothioic acid amide 
• 156459-19-7 3-cyano-6-(dimethoxymethyl)-2-pyridone 
• 70-23-5 ethyl Bromopyruvate 
• 70-11-1 α-bromoacetophenone 
• 214040-94-5 5-(4-Ethoxycarbonyl-thiazol-2-yl)-6-trifluoromethanesulfonyloxy-pyridine-2-carboxylic acid 

Downstream Products

• 214040-96-7 5-(4-Ethoxycarbonyl-thiazol-2-yl)-6-(1-ethoxy-vinyl)-pyridine-2-carboxylic acid 2-oxo-2-phenyl-ethyl ester 

Relevant articles and documents

Convenient Synthesis of the Central 3,6-Di(2-thiazolyl)-2-(4-thiazolyl)pyridine Skeleton of a Macrocyclic Antibiotic, GE 2270 A

It was shown that 6-dimethoxymethyl-1,2-dihydro-2-oxo-3-pyridinecarbonitrile (5) is easily convertible into the titled ring system by a stepwise method. Both the 3-cyano and 6-dimethoxymethyl groups of 5 were converted into 2-thiazolyl groups via the thioamide and earbaldehyde groups by Hantzsch and Shioiri methods, respectively. The 2-pyridone function was changed to a bromoacetyl group via the coupling reaction between the corresponding triilate and ethyl vinyl ether, and then converted into the 4-thiazolyl group. Thus, the useful 3,6-di(2-thiazolyl)-2-(4-thiazolyl)pyridine derivative for the total synthesis of GE 2270 A was obtained. In fact, the method was recently applied to the total synthesis of an antibiotic, micrococcin P, which has a similar central skeleton.