214045-86-0

Basic information

• Product Name: 1-CHLORO-6-FLUOROISOQUINOLINE
• Synonyms: 1-CHLORO-6-FLUOROISOQUINOLINE;Isoquinoline, 1-chloro-6-fluoro-
• CAS NO: 214045-86-0
• Molecular Formula: C₉H₅ClFN
• Molecular Weight: 181.59
• EINECS: 604-604-1
• Mol File: 214045-86-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 295.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.366±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.91±0.38(Predicted)
• CAS DataBase Reference: 1-CHLORO-6-FLUOROISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-6-FLUOROISOQUINOLINE(214045-86-0)
• EPA Substance Registry System: 1-CHLORO-6-FLUOROISOQUINOLINE(214045-86-0)

Safety Data

• Hazardous Substances Data: 214045-86-0(Hazardous Substances Data)

Usage

General Description

1-Chloro-6-fluoroisoquinoline is a chemical compound with the molecular formula C9H6ClFN. It is a heterocyclic compound containing a ring of six carbon atoms, one chlorine atom, and one fluorine atom. 1-CHLORO-6-FLUOROISOQUINOLINE has potential applications in pharmaceuticals and agrochemicals due to its diverse reactivity and potential biological activity. It can be used as a building block in the synthesis of various organic compounds, and its unique structure and properties make it a valuable intermediate in the production of complex molecules. Additionally, 1-chloro-6-fluoroisoquinoline may also be used as a research tool for studying the reactivity and properties of heterocyclic compounds.

Upstream product

• 1372215-44-5 4-fluoro-2-((trimethylsilyl)ethynyl)benzaldehyde oxime 
• 1075-11-2 6-fluoroisoquinoline 
• 214045-85-9 6-fluoro-1,2-dihydroisoquinolin-1-one 
• 1008-86-2 6-fluoroisoquinoline 2-oxide 

Downstream Products

• 848841-45-2 (4-tert-butyl-phenyl)-(6-fluoro-isoquinolin-1-yl)-amine 
• 1372215-45-6 1-(4-tert-butylphenyl)-6-fluoroisoquinoline 
• 1372215-46-7 1-(3,5-dimethylphenyl)-6-fluoroisoquinoline 
• 608515-77-1 6-fluoro-1-methylisoquinoline 

Relevant articles and documents

Preparation method of formaldehyde-substituted aza-condensed ring compound

The invention provides a preparation method of a formaldehyde-substituted aza-condensed ring compound, comprising the following steps: by using an aza-condensed ring lactam compound as a starting material, carrying out halogenation reaction, methylation reaction and methyl oxidation reaction to obtain the formaldehyde-substituted aza-condensed ring compound. According to the preparation method ofthe formaldehyde-substituted aza-condensed ring compound, the whole synthesis route is good in step repeatability, mild in operation condition and high in safety, and large-scale production and industrial popularization are facilitated; post-treatment energy consumption is low, a large amount of toxic wastewater is not generated, no pollution is caused to the environment, the production safety level and the production cost are reduced, application of green and environment-friendly industrial production is facilitated, and wide application prospects are achieved.

Isoquinoline, Quinazoline and Phthalazine Derivatives

Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R0, R5, R6, R7, n, Q1-Q5, Y, and X1-X3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.