214064-55-8Relevant academic research and scientific papers
Drug design and synthesis of ε opioid receptor agonist: 17-(cyclopropylmethyl)-4,5α-epoxy-3,6β-dihydroxy-6, 14-endoethenomorphinan-7α-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative ε opioid receptor
Fujii, Hideaki,Narita, Minoru,Mizoguchi, Hirokazu,Murachi, Miho,Tanaka, Toshiaki,Kawai, Koji,Tseng, Leon F.,Nagase, Hiroshi
, p. 4133 - 4145 (2007/10/03)
Here we report the new drug design and synthesis of a series of 6,14-endoethenomorphinan-7-carboxamide derivatives as a putative ε opioid receptor agonist. One of these compounds, 17-(cyclopropylmethyl)-4,5α- epoxy-3,6β-dihydroxy-6,14-endoethenomorphinan-
Cinnamoyl derivatives of 7a-amino- and 7a-(aminomethyl)- N-(cyclopropylmethyl)-6,14-endo-ethanotetrahydronororipavines are high-potency opioid antagonists
Derrick, Ian,Husbands, Stephen M.,Broadbear, Jillian,Traynor, John R.,Woods, James H.,Lewis, John W.
, p. 3122 - 3130 (2007/10/03)
Methods have been developed for the synthesis of 7a-amino- and 7a-(aminomethyl)-N-cyclopropylmethyl-6.14-endo-ethanotetrahydronororipavines and their cinnamoyl derivatives (Schemes 1 and 3). In displacement binding assays, the cinnamoyl derivatives 4c and
