21413-15-0

Usage

Uses

Used in Pharmaceutical Research:
6-CHLOROTETRAZOLO[1,5-B]PYRIDAZINE is used as a key intermediate in the synthesis of various biologically active compounds for pharmaceutical applications. Its unique structure and chemical properties make it a valuable component in the development of new drugs.
Used in Drug Discovery:
In the field of drug discovery, 6-CHLOROTETRAZOLO[1,5-B]PYRIDAZINE is utilized as a starting material for the creation of potential therapeutic agents. Its presence in molecular structures can contribute to the desired pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Cancer Treatment Development:
6-CHLOROTETRAZOLO[1,5-B]PYRIDAZINE is used as a component in the development of new drugs for treating cancer. Its incorporation into drug molecules can potentially enhance their ability to target and combat cancer cells.
Used in Anti-Inflammatory Drug Development:
6-CHLOROTETRAZOLO[1,5-B]PYRIDAZINE is also used in the development of anti-inflammatory drugs, where its structure may contribute to the modulation of inflammatory pathways and provide therapeutic benefits for conditions characterized by inflammation.
Used in Antimicrobial Drug Development:
6-CHLOROTETRAZOLO[1,5-B]PYRIDAZINE is utilized in the creation of antimicrobial agents, potentially offering new solutions for treating microbial infections, including those caused by drug-resistant strains.

InChI:InChI=1/C4H2ClN5/c5-3-1-2-4-6-8-9-10(4)7-3/h1-2H

Upstream product

• 17284-97-8 3-Chloro-6-hydrazinopyridazine 
• 64-19-7 acetic acid 

Downstream Products

• 274-89-5 tetrazolo[1,5-b]pyridazine 
• 61330-25-4 5H-tetrazolo[1,5-b]pyridazin-6-one 
• 57634-64-7 6-(4-nitro-phenoxy)-tetrazolo[1,5-b]pyridazine 
• 19195-43-8 6-Amino-tetrazolo<1,5-b>pyridazin 
• 132846-45-8 6-Chloro-9-methyl-9-phenyl-6a,9a-dihydro-9H-pyrazolo<4,3-d>tetrazolo<1,5-b>pyridazine 
• 132846-49-2 6-Chloro-9-methyl-9-phenyl-9H-pyrazolo<4,3-d>tetrazolo<1,5-b>pyridazine 
• 132846-39-0 7-Benzyl-6-chloro-9-phenyl-7H-pyrazolo<4,3-d>tetrazolo<1,5-b>pyridazine 
• 132846-40-3 8-Benzyl-6-chloro-9-phenyl-8H-pyrazolo<4,3-d>tetrazolo<1,5-b>pyridazine 

Relevant academic research and scientific papers

Medicine composition for treating cardiac failure and preparation method and use thereof

The invention relates to a medical composition for treating cardiac failure. The medical composition comprises compounds having the following structure and auxiliary components (as shown in the description) commonly used for pharmacy. The invention further relates to a preparation method and use of the medical composition. The pharmacological action of the medical composition on heart and cerebralvessel systems is mainly represented in the respects of strengthening the heart function, protecting cardiac muscle cells, regulating blood pressure, regulating the vasomotoricity, resisting blood coagulation, resisting thrombosis, reducing blood lipid, resisting atherosclerosis, improving cerebral circulation and the like. The function of reinforcing myocardium relaxation and contraction is reinforced, so that the peripheral resistance is reduced, and the heart failure degree is continuously improved, so that the medical composition achieves treatment effect on the heart failure.

Multinuclear magnetic resonance study of the structure and tautomerism of azide and iminophosphorane derivatives of chloropyridazines

Some azido- and iminophosphorane derivatives of 3,6-dichloro- and 3,4,5,6-tetrachloropyridazine were synthesized and studied by means of NMR measurements. Based on multinuclear data (chemical shifts, coupling constants) for compounds containing the azide group, no potentially possible tetrazole-azide equilibrium can be observed, even under acidic conditions. An unusual substitution of a chlorine atom (in position 4) of tetrachloropyridazine in the reaction with hydrazine was demonstrated by NMR measurements of two newly synthesized compounds containing azido- and iminophosphorane groups. Using multinuclear magnetic resonance data, the sites of ethylation and protonation of azido- and iminophosphorane derivatives of chloropyridazines were established. In the case of the tetrazolopyridazines, ethylation occurs at the N1′ and N2′ atoms, whereas for monocyclic compounds it takes place at the N1 and/or N2 atoms of the pyridazine ring. Preferred sites of protonation are the N1′ atom of the tetrazole ring and the N1 atom of the pyridazine ring. Moreover, the structures of potassium salts of 6-(3-cyano-1-triazeno)tetrazolo[1,5-b] pyridazine and its amido derivative were established using NMR data, especially 15N NMR chemical shifts. Copyright

Triazolo- and tetrazolopyridazine derivatives and their hypotension and heart rate activity

6-Chloro-, 6-morpholino- and 6-N-methylpiperazino-1,2,4-triazolo[4,3-b]- or 1,2,3,4-tetrazolo [1,5-b]pyridazines [II-VII] were synthesized from 3-chloro-6-hydrazinopyridazine [I]. Positive effect of a series of tetra- and triazolopyridazines for lowering blood-pressure without affecting the heart rate was found in tests on rats. Their lipophilicity and other properties are discussed.

Reactivity of triazolo- and tetrazolopyridazines

Azolopyridazine derivatives obtained in the reactions of 3-chloro-6-hydrazinopyridazine with formic acid, acetic acid, and nitrous acid are described. By treating triazolo- and tetrazolopyridazines with hydrazine or morpholine, corresponding derivatives s

NOUVEAUX DERIVES PYRIDAZINIQUES ET PHTALAZINIQUES DOUES D'ACTIVITE PHYSIOLOGIQUE

This paper reports eleven new pyridazines and phthalazines derivatives. Products 5-11 have been obtained starting from 3-chloro-6-hydrazino-pyridazine (4), by means of various reactions. Products 14-16 belong to the class of phthalazinium-ylids. The biolo

7-[α-(2-Aminomethyl-1-cyclohexenyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids

7-[α-(2-Aminomethyl-1-cyclohexyl)-acetamido]-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acids, and their nontoxic, pharmaceutically acceptable salts and their Schiff bases, as made by reaction of salicylaldehyde with the free amino group, are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.