214143-72-3Relevant academic research and scientific papers
N-(2-nitrophenyl)proline: An intramolecular hydrogen bond forming reagent for the determination of the absolute configuration of primary amines
Ahn, Hee Choon,Choi, Kihang
, p. 3853 - 3855 (2007)
N-(2-Nitrophenyl)proline (2-NPP) amides of primary amines have a conformational preference for intramolecular hydrogen bonding. Because of the strong and selective anisotropic effects on the amine substituents, the absolute configuration of α-chiral primary amines can be assigned by comparing the 1H chemical shifts of diastereomeric 2-NPP amides.
Biphenyl derivatives and drug composition
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, (2008/06/13)
A biphenyl derivative represented by the following general formula (1) and a pharmaceutically acceptable salt thereof: [In the formula (1), A represents a single bond, —CH2—, —CO—, —CS— or —SO2—; B represents a single bond or —CH2—; R1represents a hydrogen atom, —OH, —NR11R12(wherein R11and R12each independently represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms), —OCOCH3, or a halogen atom; R2represents a hydrogen atom or R1and R2form a group ═O together; R3represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; provided that in the formula, the absolute configuration of the position a may be either R or S]. The compound of the present invention has considerably high safety and efficacy and is useful as, in particular, a vasopressin receptor antagonist.
