214147-48-5

Basic information

• Product Name: 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL
• Synonyms: 1-Acetylpiperidin-4-amine hydrochloride;1-Acetyl-4-aminopiperidine hydrochloride;1-Acetyl-4-aminopiperidine hyd;1-(4-AMino-1-piperidinyl)-ethanone HCl;1-(4-Aminopiperidin-1-yl)ethanone hydrochloride;1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL;1-(4-aminopiperidin-1-yl)ethan-1-one hydrochloride
• CAS NO: 214147-48-5
• Molecular Formula: C₇H₁₄N₂O*ClH
• Molecular Weight: 178.6598
• EINECS: 1806241-263-5
• Mol File: 214147-48-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 231-234℃
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL(214147-48-5)
• EPA Substance Registry System: 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL(214147-48-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 214147-48-5(Hazardous Substances Data)

Usage

General Description

1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL is a chemical compound with the molecular formula C10H17ClN2O. It is a derivative of piperidine and is used in the synthesis of various pharmaceuticals and organic compounds. The HCL form of the compound is a hydrochloride salt, which is commonly used to enhance the stability and solubility of the compound. It is a white crystalline powder that is soluble in water and has a wide range of applications in the pharmaceutical and chemical industries. 1-(4-AMINO-PIPERIDIN-1-YL)-ETHANONE HCL is commonly used as an intermediate in the synthesis of various drugs and organic compounds due to its versatile reactivity and stability.

Upstream product

• 283167-28-2 tert-butyl (1-acetylpiperidin-4-yl)carbamate 
• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 

Downstream Products

• 283167-05-5 1-acetyl-4-(4-fluorophenoxycarbonylamino)piperidine 
• 1884246-71-2 6-((1-acetylpiperidin-4-yl)amino)pyrimidine-4-carboxylic acid 
• 283167-10-2 1-(1-acetyl-piperidin-4-yl)-3-(4-fluoro-phenyl)-urea 
• 283167-06-6 N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide 

Relevant articles and documents

TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS

A compound of formula (I) wherein: R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The invention relates to a compound of formula (I) or a salt thereof: wherein:R1 is C1-4alkyl, C1-3fluoroalkyl, -CH2CH2OH or -CH2CH2CO2C1-2alkyl;R2 is a hydrogen atom (H), methyl or C1fluoroalkyl;R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): ; and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.