214221-35-9Relevant academic research and scientific papers
Synthesis of polysubstituted pyrroles via phi(OAC)2-mediated oxidative coupling of enamine esters and ketones
Wang, Jun-Yan,Liu, Su-Ping,Yu, Wei
experimental part, p. 2529 - 2533 (2010/02/28)
Enamine esters or ketones could undergo homocoupling by the action of (diacetoxyiodo)benzene in the presence of BF3OEt2, giving rise to pyrrole products. This reaction could be used to synthesize symmetric polysubstituted pyrroles. Some asymmetric polysub
Synthesis of functionalized pyrroles by reaction of 3,4-diacetylhexane-2,5- dione with primary amines in water
Yavari, Issa,Sabbaghan, Maryam
, p. 1791 - 1800 (2008/02/02)
3,4-Diacetylhexane-2,5-dione (tetra-acetylethane) undergoes a complex reaction with primary amines in boiling water to produce N-alkyl-3-acetyl-2,5- dimethylpyrroles, together with small quantities of N-alkyl-3,4-diacetyl-2,5- dimethylpyrroles and 2,5-dim
Hypervalent iodine in synthesis 72: A tandem dimerisation-cyclocondensation of enaminones with [bis(trifluoroacetoxy)iodo]benzene: An effective method for the synthesis of highly substituted pyrroles
Zhang,Chen
, p. 150 - 152 (2007/10/03)
A tandem dimerisation-cyclocondensation of enaminones with [bis(trifluoroacetoxy)iodo]benzene(BTI) provides an effective method for the synthesis of highly substituted pyrroles. It has some advantages over existing methodologies such as accessible starting material, nontoxic reagents, mild reaction conditions.
3,4-Diacetylhexane-2,5-dione - An effective synthon for synthesis of substituted azulene heteroanalogs by cyclocondensation reactions
Olekhnovich,Boroshko,Tkachenko,Pozharskii,Tsupak,Zhdanov,Olekhnovick
, p. 1553 - 1560 (2007/10/03)
The one-pot method for the synthesis of 4,8-dialkoxy-6-aryl-1,3-dimethylcyclohepta[c]furanium perchlorates has been developed. The method is based on the cyclocondensation of 3,4-diacetylhexane-2,5-diones with aromatic aldehydes and trialkyl orthoformates under the action of a 16% perchloric acid solution in acetic anhydride. Under similar conditions, with hydrogen sulfide, cyclohepta[c]thiophenium perchlorates have been obtained, while cyclohepta[c]pyrrolium perchlorates have been prepared with arylamines, ammonium acetate, or aliphatic amine acetates. A heteroanalog of azulene, 4,8-diethoxy-1,3-dimethyl-2-azaazulene, has been obtained for the first time. Hydrolysis of aza- and thiaazulenium salts gives the corresponding cyclohepta[c]pyrrol-4-ones and cyclohepta[c]thiophen-4-ones.
