21424-91-9

Usage

InChI:InChI=1/C13H15ClN2O2/c1-18-10-2-3-12-11(6-10)9(8-16-12)4-5-15-13(17)7-14/h2-3,6,8,16H,4-5,7H2,1H3,(H,15,17)

Upstream product

• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 
• 79-04-9 chloroacetyl chloride 
• 58635-45-3 methyl 2-(1-H-indol-3-yl)ethylcarbamate 
• 67199-10-4 methyl N-[2-(5-methoxy-1H-indol-3-yl)ethyl]carbamate 
• 180910-53-6 1-hydroxy-N_b-methoxycarbonyltryptamine 
• 180910-64-9 2,3-dihydro-Nb-methoxycarbonyltryptamine 
• 50-67-9 3-(2-aminoethyl)-1H-indol-5-ol 

Relevant academic research and scientific papers

8-aminoquinoline-melatonin complex and pharmaceutical composition thereof

The invention relates to synthesized 8-aminoquinoline-melatonin complex, in particular to an 8-aminoquinoline-melatonin complex and a pharmaceutical composition thereof. The 8-aminoquinoline-melatonin complex is of a structure as shown in the structural formula (I); on one hand, the compounds can selectively chelate copper ions; on the other hand, the compounds play a role in well protecting nerves and nerve cells to improve AD (Alzheimer's disease) symptoms. The invention further relates to a pharmaceutical composition or nerve cell protective agent comprising the complex or pharmaceutically acceptable salt thereof. The invention further relates to pharmaceutical application of the complex.

Syntheses of melatonin and its derivatives

Two simple synthetic methods for melatonin are newly developed from tryptamine through intermediates, which are promising lead compounds for drug developing research. Novel chemical reactivities of melatonin in its bromination, lithiation, and acylation are also reported.