214336-97-7Relevant academic research and scientific papers
Design and synthesis of pyrrolidine-5,5′-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability
Borthwick, Alan D.,Davies, Dave E.,Ertl, Peter F.,Exall, Anne M.,Haley, Terry M.,Hart, Graham J.,Jackson, Deborah L.,Parry, Nigel R.,Patikis, Angela,Trivedi, Naimisha,Weingarten, Gordon G.,Woolven, James M.
, p. 4428 - 4449 (2007/10/03)
A series of chiral, (S)-proline-α-methylpyrrolidine-5,5-trans-lactam serine protease inhibitors has been developed as antivirals of human cytomegalovirus (HCMV). The SAR of the functionality on the proline nitrogen has shown that derivatives of para-subst
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality
Borthwick,Crame,Ertl,Exall,Haley,Hart,Mason,Pennell,Singh,Weingarten,Woolven
, p. 1 - 18 (2007/10/03)
The stereospecific synthesis of a series of α-methylpyrrolidine-5,5-trans-lactam inhibitors of human cytomegalovirus (HCMV) protease is described. Examination of the SAR in this series has defined the size and chirality of the α-substituent, optimized the
