214337-01-6

Upstream product

• 214337-00-5 (3aR,6aS)-2-oxohexahydropyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 214336-97-7 (3aS,6S,6aR)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester 
• 214337-06-1 benzyl (3aS,6S,6aR)-4-{[cis-2,3-dimethylcyclopropyl]-cis-carbonyl}-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate 
• 214337-02-7 benzyl (3aS,6S,6aR)-4-(cyclopropylcarbonyl)-6-methyl-5-oxohexahydropyrrolo[3,2-b]pyrrole-1(2H)-carboxylate 

Relevant academic research and scientific papers

Stereoselective synthesis of gem-dimethyl-5,5-pyrrolidine-trans-lactam (5-oxo-hexahydropyrrolo[3,2-b]pyrrole)

The gem-dimethyl-trans-lactam 6 could be prepared by alkylation of the β-methyl isomer 7 but not by alkylation of the α-isomer 5.

Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality

The stereospecific synthesis of a series of α-methylpyrrolidine-5,5-trans-lactam inhibitors of human cytomegalovirus (HCMV) protease is described. Examination of the SAR in this series has defined the size and chirality of the α-substituent, optimized the