214344-28-2Relevant academic research and scientific papers
Preparation and properties of enantiomerically pure Nα-tritylamino acid fluorides
Karygiannis, Georgios,Athanassopoulos, Costas,Mamos, Petros,Karamanos, Nikolaos,Papaioannou, Dionissios,Francis, George W.
, p. 1144 - 1150 (2007/10/03)
Cyanuric fluoride-mediated fluorination of chiral Nα-tritylamino acids leads to the corresponding acyl fluorides which are powerful acylating agents for peptide synthesis. The acyl fluorides react with NaBH4, the stabilized phosphorane Ph3P=C(Me)CO2Me and Ruppert's reagent providing access to enantiomerically pure tritylamino alcohols, alkenes and trifluoromethyl ketones, respectively. Acta Chemica Scandinavica 1998.
