214357-95-6 Usage
Uses
Used in Pharmaceutical Industry:
3-Pyrrolidinamine,1-methyl-,(3S)-(9CI) is used as a key intermediate in the synthesis of various drugs and active pharmaceutical ingredients. Its unique stereochemistry and reactivity contribute to the development of new and innovative medications.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Pyrrolidinamine,1-methyl-,(3S)-(9CI) serves as a versatile building block for the creation of complex organic molecules. Its specific (3S) configuration allows for the formation of enantioselective products, which are essential in the synthesis of chiral compounds with biological activity.
Used in Drug Development:
3-Pyrrolidinamine,1-methyl-,(3S)-(9CI) is employed in drug development for its potential applications in the creation of new therapeutic agents. Its unique properties and reactivity enable the design and synthesis of novel drug candidates with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 214357-95-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,3,5 and 7 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 214357-95:
(8*2)+(7*1)+(6*4)+(5*3)+(4*5)+(3*7)+(2*9)+(1*5)=126
126 % 10 = 6
So 214357-95-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H12N2/c1-7-3-2-5(6)4-7/h5H,2-4,6H2,1H3/t5-/m0/s1
214357-95-6Relevant academic research and scientific papers
Hegarty, Eimear,Paradisi, Francesca
, p. 890 - 894 (2020)
Significant progress has been made in establishing transaminases as robust biocatalysts for the green and scalable synthesis of a diverse range of chiral amines.[1] However, very few examples on the amination of small cyclic ketones have been reported.[2] Cyclic ketones are particularly challenging for transaminase enzymes because they do not display the well-defined small and large substituent areas that are characteristic for the biocatalytic mechanism. In this work, we exploited the broad substrate scope of the (S)-selective transaminase from Halomonas elongata (HeWT) to develop an efficient biocatalytic system in continuous flow to generate a range of small cyclic amines which feature very often in pharmaceuticals and agrochemicals.[3] Tetrahydrofuran-3-one and other challenging prochiral ketones were rapidly (5-45 min) transformed to their corresponding amines with excellent molar conversion (94-99%) and moderate to excellent ee.
