68165-06-0

Basic information

• Product Name: 1-Methylpyrrolidin-3-one
• Synonyms: 1-methyl-3-pyrrolidinone;3-Pyrrolidone, 1-methyl-;1-METHYL-3-PYRROLIDONE;3-Pyrrolidinone, 1-methyl-;1-Methylpyrrolidin-3-one
• CAS NO: 68165-06-0
• Molecular Formula: C₅H₉NO
• Molecular Weight: 99.13
• EINECS: 1533716-785-6
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 68165-06-0.mol

Chemical Properties

• Boiling Point: 185.62°C (rough estimate)
• Flash Point: 42°(108°F)
• Appearance: /
• Density: 0.984 g/mL at 25 °C
• Vapor Pressure: 4.14mmHg at 25°C
• Refractive Index: n20/D1.451
• Storage Temp.: ?20°C
• PKA: 6.51±0.20(Predicted)
• CAS DataBase Reference: 1-Methylpyrrolidin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methylpyrrolidin-3-one(68165-06-0)
• EPA Substance Registry System: 1-Methylpyrrolidin-3-one(68165-06-0)

Safety Data

• Hazard Codes: Xi
• Statements: 10-37/38-41-43
• Safety Statements: 26-36/37/39
• RIDADR: UN 1993C 3 / PGIII
• WGK Germany: 2
• HazardClass: 3
• Hazardous Substances Data: 68165-06-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Methylpyrrolidin-3-one is used as a solvent for the production of pharmaceuticals, facilitating the manufacturing process and improving the solubility of certain active ingredients.
Used in Polymer Industry:
In the polymer industry, 1-Methylpyrrolidin-3-one serves as a solvent, aiding in the synthesis and processing of various polymers, which are essential in the production of plastics and other materials.
Used in Electronics Industry:
1-Methylpyrrolidin-3-one is utilized as a solvent in the electronics industry, particularly for cleaning and stripping processes, ensuring the removal of unwanted materials and residues from electronic components.
Used as a Paint Stripper:
Due to its strong solvent properties, 1-Methylpyrrolidin-3-one is used as a paint stripper, effectively removing paint from various surfaces without causing significant damage.
Used as a Cleaning Agent:
Its ability to dissolve a wide range of substances makes 1-Methylpyrrolidin-3-one a useful cleaning agent in various industrial settings, where it helps to remove dirt, grease, and other contaminants.
However, it is important to note that 1-Methylpyrrolidin-3-one has been identified as a potential reproductive hazard. As a result, it is subject to regulations in some jurisdictions due to its toxicity and potential health risks. Therefore, it is crucial to handle and use this chemical with caution, adhering to relevant safety guidelines and regulations to minimize exposure and ensure the safety of workers and the environment.

InChI:InChI=1/C5H9NO/c1-6-3-2-5(7)4-6/h2-4H2,1H3

Upstream product

• 24286-82-6 [(2-cyanoethyl)methylamino]acetic acid ethyl ester 
• 13220-25-2 1-methyl-4-oxo-pyrrolidine-3-carboxylic acid ethyl ester; hydrochloride 
• 120-94-5 1-Methylpyrrolidine 
• 13220-33-2 1-methyl-3-pyrrolidinol 
• 102153-86-6 N-ethylpyrrolidin-3-one 
• 13220-24-1 3-((ethoxycarbonylmethyl)methylamino)propionic acid ethyl ester 

Downstream Products

• 91564-48-6 3-(4-methoxy-phenyl)-1-methyl-pyrrolidin-3-ol 
• 939776-25-7 3-amino-1-methylpyrrolidine-3-carbonitrile 
• 214357-95-6 (S)-1-methylpyrrolidin-3-ylamine 
• 104641-59-0 (3S)-1-methylpyrrolidin-3-ol 
• 25113-03-5 3-(2,6-diphenyl-pyran-4-ylidene)-1-methyl-pyrrolidin-2-one 

Relevant articles and documents

Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors

The synthesis and in vitro activities of a series of succinyl-nitrile-based inhibitors of Cathepsin S are described. Several members of this class show nanomolar inhibition of the target enzyme as well as cellular potency. The inhibitors displaying the greatest potency contain N-alkyl substituted piperidine and pyrrolidine rings spiro-fused to the α-carbon of the P1 residue.

Chiral arylpyrrolidinols: Preparation and biological profile

The preparation and biological evaluation of a new class of arylpyrrolidinols is reported. The antinociceptive activity was evaluated in vivo with the hot plate test (HPT) and formalin test (FT), excluding any involvement on motor coordination with the rota-rod test (RRT). The nociceptive behavior in the late phase of FT (representative of chronic pain) suggests an involvement of the antiinflammatory process and it is clearly influenced by the stereochemical features, being the eutomer of phenylpyrrolidinols, the (2R,3S) enantiomer. Despite this, a specific mechanism of action is not yet clarified.

6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives

The present invention concerns compounds of the formula: STR1 wherein R is a lower alkyl group, an aryl group or an alkylaryl group and X and Y are the same or different, and each is OH, NH2, or SH. The aryl group or the aryl moiety of the alkylaryl group may be unsubstituted, monosubstituted, disubstituted or trisubstituted. If substituted, each substituent may independently be an alkyl group, an alkyloxy group or a halogen. The present invention also provides methods for synthesizing the compounds described above.

ON THE GIF OXIDATION OF ALICYCLIC TERTIARY AMINES

Oxidation of various tertiary amines by the GifIV system based on iron catalyst associated with a reductant (zinc) and molecular oxigen, led to a mixture of the keto-derivatives and the corresponding lactams.Steric hindrance and electron withdrawing substituents exert a deactivating effect on the oxidation.

N-Heterocyclic-9-xanthenylamines

The compounds are N-piperidinyl and pyrrolidinyl-9-xanthenylamines which are inhibitors of gastric acid secretion.