2144-96-9Relevant academic research and scientific papers
Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors
Cusan, Claudia,Spalluto, Giampiero,Prato, Maurizio,Adams, Michael,Bodensieck, Antje,Bauer, Rudolf,Tubaro, Aurelia,Bernardi, Paolo,Da Ros, Tatiana
, p. 327 - 332 (2005)
A series of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5- one as potential human 5-LOX and COX 1 and COX-2 inhibitors structurally related to the 1-phenyl-3-pyrazolidinone (phenidone, 1) have been synthesized and the activity against COX-
Synthesis and purification of 3-N-acylaminopyrazolinones using a sequence of functionalized polymers
Fu, Jiasheng,Shuttleworth, Stephen J.
, p. 3843 - 3845 (2003)
A parallel synthesis route to 3-acylaminopyrazolinones using a sequence of functionalized polymers has been developed. The polymers were utilized as both stoichiometric reagents and purification agents to allow for the clean formation of the desired target compounds.
New series of antiprion compounds: Pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation
Kimata, Ayako,Nakagawa, Hidehiko,Ohyama, Ryo,Fukuuchi, Tomoko,Ohta, Shigeru,Suzuki, Takayoshi,Miyata, Naoki
, p. 5053 - 5056 (2008/03/13)
To find effective antiprion compounds, we synthesized and evaluated various pyrazolone derivatives. Seven of 19 compounds showed inhibition of PrP-res accumulation and the remarkably active compound 13 showed an IC50 value of 3 nM in both ScN2a and F3 cell lines. Findings from studies on physicochemical and biochemical properties suggest that the action mechanism of these compounds does not correlate with any antioxidant activities, any of hydroxyl radical scavenging activities, or any SOD-like activities.
